SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… tissue-types and organ systems to SARS-CoV-2 attack in this … malfunction and severe
respiratory failure that is lethal in … replication, survival and spread by exploiting the presence of …

Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
… acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In … [1,2], after which the new
coronavirus spread globally and was … Endothelial damage is an important culprit in multi-organ

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

T Mokhtari, F Hassani, N Ghaffari, B Ebrahimi… - Journal of molecular …, 2020 - Springer
… the multi-organ failure and related symptoms induced by SARS-CoV2 in severe patients. …
rate, BUN blood urea nitrogen, DIC disseminated intravascular coagulation, VTE venous …

Animal models for SARSCoV2 infection and pathology

Z Bi, W Hong, J Yang, S Lu, X Peng - MedComm, 2021 - Wiley Online Library
… with SARS-CoV-2, leading to multiple organ injury. K18-… the SARS-CoV-2 infection in
peripheric leukocytes of mice as early as 1 dpi, which contributes to the systemic viral dissemination

An integrative look at SARSCoV2

MA Ortega, O Fraile‑Martínez… - International …, 2021 - spandidos-publications.com
… will we be able to curb the spread of SARS-CoV-2 (42,43). The … lung damage which in turn
will facilitate virus dissemination (… of the organs that more significantly expresses the ACE-2

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

J Meinhardt, J Radke, C Dittmayer, J Franz… - Nature …, 2021 - nature.com
… the COVID-19 autopsy cases investigated here, SARS-CoV-2 in the CNS endothelium might
facilitate vascular damage and allow the virus to spread … sampling of each organ and region …

Disentangling the hypothesis of host dysosmia and SARS-CoV-2: the bait symptom that hides neglected neurophysiological routes

M Briguglio, A Bona, M Porta, B Dell'Osso… - Frontiers in …, 2020 - frontiersin.org
… of COVID-19. The largest pial vessels and smallest brain capillaries allow the virus to spread,
and injuries … , multiple organ dysfunction, immunoincompentence, and fatal consequences. …

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

P Wang, R Luo, M Zhang, Y Wang, T Song, T Tao… - Cell death & …, 2020 - nature.com
… Though SARS-CoV-2 infection is localized primarily to the respiratory system, there is an
increasing evidence of systemic dissemination of the virus to multiple organs, such as …

The possible role of microbial proteases in facilitating SARS-CoV-2 brain invasion

N Mjokane, OS Folorunso, AO Ogundeji, OM Sebolai - Biology, 2021 - mdpi.com
… The respiratory failure caused by the novel coronavirusSARS-CoV-2 may disseminate
to invade other organ systems. Herein, we speculated that patients infected with SARS-CoV-2

An update on SARS-CoV-2/COVID-19 with particular reference to its clinical pathology, pathogenesis, immunopathology and mitigation strategies

K Dhama, SK Patel, M Pathak, MI Yatoo… - Travel medicine and …, 2020 - Elsevier
SARS-CoV-2 has spread rapidly through travellers to more than 200 countries across the …
other organs were also reported [127]. Microscopically SARS-CoV-2 has shown to damage