… Organic anion transporters (OATs) belong to the solute carrier (SLC) 22 superfamily and
facilitate organic anions … transport of anionic and zwitterionic organic molecules, including …

… of drug–drug interactions (DDI). Since many statins are substrates of uptake transporters of
the organic anion-… coadministration of cholesterol-lowering drugs with other OATP substrates …

… The family of organic anion transporters (OATs in humans, Oats in animals) includes a …
and besides organic anion comprises the organic cation transporters and organic carnitine …

… and understanding of the potential for drug interactions. Recent publications provide insight
… ) and human organic anion-transporting polypeptides (OATPs) in drug interactions. Active …

… Organic anion-transporting polypeptide 4C1 (OATP4C1) is an organic anion transporter
expressed in the basolateral membrane of the renal proximal tubules. It plays a major role in the …

… of many registered drugs and are, therefore, of great relevance for drug safety and efficacy.
… of interactions with transporters already at the drug discovery stage. The organic anion …

… clearances of anionic drugs and renal drug-drug interactions. It … Tubular secretion of organic
anions involves uptake and … that the renal uptake clearance of anionic drugs is close to the …

… kidney 293 cells transfected with human or rat organic anion transporter 3 (hOAT3, rOat3)
revealed … Therefore, the potential for a drug-drug interaction (DDI) between gemcabene with …

… Traditionally, inhibition of major drug … focus of drug–drug interaction studies. Newly
recognized, additional determinants of drug disposition are uptake transporters of the organic anion …

… This review will deal only with those OATs for which transport of organic anions has been
shown experimentally, ie OATs1–4, OAT7, OAT10, and URAT1 in humans (upper case lettering…