… Metallo-β-lactamases are the latest resistance mechanism of … the three known subclasses
of metallo-β-lactamases, analyzed … These are common mechanistic elements in all metallo-β-…

… Importantly, differences in mechanism can impact pharmacology in terms of reversibility, …
The lack of effective treatments to overcome MBL-mediated resistance is an unmet clinical need …

… various experiments to characterize differences between NDM-1,-4, and-12; the data have
been published. 30 Using at least one compound from three classes of β-lactams: ampicillin (…

… small difference in the X-ray crystal structure (<1 Å movement of a β-… differences in B-factors
for residues surrounding the active site, including the 154 and 222 sites or the neighboring β-…

… The cell must overcome challenges imposed by the relative stability of complexes formed by
… Electronic differences between the two metals and the subtle differences in the geometries …

… hydrolyze β-lactams varies considerably. The most noticeable example of this is the difference
… For instance, VIM-2 tends to bind most β-lactams more tightly than VIM-1 and possesses …

… group (Figure 1) and was developed to overcome resistance against cisplatin and carboplatin.
… It was later shown that there are significant differences between the two types of antitumor …

… differences in the adduct geometries, and in their relative binding strengths [Citation17]. A
possible alternative to overcome … -link, characterizing the structural differences with respect to …

… We assume that the differences between the potential energy values do not differ considerably
from the corresponding free energy values (ΔG), since all chemical transformations are …

… to compare the mechanistic differences across MβL subclasses … We attribute this difference
to the involvement of a metal-… mechanistic features, overcoming the challenge posed by the …