p-Coumaric Acid and Ursolic Acid from Corni fructus Attenuated β-Amyloid25–35-Induced Toxicity through Regulation of the NF-κB Signaling Pathway in PC12 …

JH Yoon, K Youn, CT Ho, MV Karwe… - Journal of agricultural …, 2014 - ACS Publications
Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes
in the pathogenesis of Alzheimer's disease (AD). Blockade of Aβ has emerged as a possible
therapeutic approach to control the onset of AD. This study investigated the neuroprotective
effects and molecular mechanisms of p-coumaric acid (p-CA) and ursolic acid (UA) from
Corni fructus against Aβ25–35-induced toxicity in PC12 cells. p-CA and UA significantly
inhibited the expression of iNOS and COX-2 in Aβ25–35-injured PC12 cells. Blockade of …
被引用次数：133 相关文章 所有 8 个版本

p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid25-35-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells.

YJH Yoon JeongHyun, YKJ Youn KumJu… - 2014 - cabidigitallibrary.org
Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes
in the pathogenesis of Alzheimer's disease (AD). Blockade of Aβ has emerged as a possible
therapeutic approach to control the onset of AD. This study investigated the neuroprotective
effects and molecular mechanisms of p-coumaric acid (p-CA) and ursolic acid (UA) from
Corni fructus against Aβ25-35-induced toxicity in PC12 cells. p-CA and UA significantly
inhibited the expression of iNOS and COX-2 in Aβ25-35-injured PC12 cells. Blockade of …
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