p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation
JLE Dean, SJ Sarsfield, E Tsounakou… - Journal of Biological …, 2003 - ASBMB
AU-rich elements (AREs) in 3′-untranslated regions of mRNAs confer instability. They
target mRNAs for rapid deadenylation and degradation and may enhance decapping. The
p38 MAPK pathway stabilizes many otherwise unstable ARE-containing mRNAs encoding
proteins involved in inflammation; however, the mRNA decay step (s) regulated by the
signaling pathway are unknown. To investigate whether it regulates deadenylation or the
decay of the mRNA body, we used a tetracycline-regulated β-globin mRNA reporter system …
target mRNAs for rapid deadenylation and degradation and may enhance decapping. The
p38 MAPK pathway stabilizes many otherwise unstable ARE-containing mRNAs encoding
proteins involved in inflammation; however, the mRNA decay step (s) regulated by the
signaling pathway are unknown. To investigate whether it regulates deadenylation or the
decay of the mRNA body, we used a tetracycline-regulated β-globin mRNA reporter system …
以上显示的是最相近的搜索结果。 查看全部搜索结果