… To further assess the breadth of fusion inhibitory activity, as demonstrated by EK1, we
established cell-cell fusion assays mediated by the S protein of these SL-CoVs (fig. S2). Notably, …

… a pan-coronavirus fusion inhibitor, EK1, which targeted the HR1 domain and could inhibit …
was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane …

… -based pan-CoV fusion inhibitors with high proteolytic … -based pan-CoV fusion inhibitors
with oral bioavailability. … -20-1 potently inhibited cell–cell fusion mediated by S protein of …

… presents a spike protein (S) on the viral membrane surface. S … fusion inhibitor inhibits the
membrane fusion process by blocking 6-HB formation Anti-coronavirus peptide fusion inhibitors …

… a Schematic structure of SARS-CoV-2 spike protein. The conserved glycosylation sites
within the SARS-CoV-2 S2 subunit are shown and marked as ψ. b Conformational transition of …

… Pan-coronavirus fusion inhibitors, targeting the conserved heptad repeat 1 (HR1) in spike
protein S2 subunit, can broadly and potently inhibit … of pan-coronavirus fusion inhibitors, such …

… -based drug, it is essential to identify a conserved and common target site in the spike (S)
proteins of HCoVs, since S protein, which consists of S1 and S2 subunits (Fig. 1A), is …

… To explore whether EK1 peptides are antivirally active against infection mediated by
spike protein carrying these mutations, we assessed their antiviral efficacy on infection by …

… To enter the host target cell, SARS-CoV-2 utilizes spike (S) protein to recognize the … S protein
a promising target for developing antiviral drugs (Walls et al. 2020). SARS-CoV-2 S protein …

… Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using
spike protein heptad repeat-derived peptides. Proc Natl Acad Sci USA. 2004;101:8455–8460. …