Micro-and nanotechnology approaches to improve Parkinson's disease therapy

PV Torres-Ortega, L Saludas, AS Hanafy… - Journal of controlled …, 2019 - Elsevier
… Current therapies for Parkinson's disease are symptomatic and unable to regenerate the
brain tissue. In recent years, the therapeutic potential of a wide variety of neuroprotective and …

The proNGF-p75NTR-sortilin signalling complex as new target for the therapeutic treatment of Parkinson's disease

LW Chen, KKL Yung, YS Chan… - CNS & Neurological …, 2008 - ingentaconnect.com
… of substantia nigra neurons or disease progression of Parkinson's disease (PD). In addition,
… neurons and improved disease progression of the neurodegenerative diseases Alzheimer's …

Progress towards therapies for disease modification in Parkinson's disease

N Vijiaratnam, T Simuni, O Bandmann… - The Lancet …, 2021 - thelancet.com
… of Parkinson's disease pathogenesis … Parkinson's disease that are also aberrant in
sporadic cases. From this finding emerges a key concept regarding whether Parkinson's disease

Prospects for antiapoptotic drug therapy of neurodegenerative diseases

PC Waldmeier - Progress in Neuro-Psychopharmacology and …, 2003 - Elsevier
… The evidence for a role of apoptosis in the neurodegenerative diseases, Alzheimer's disease
(AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and in the more …

[HTML][HTML] Neural stem cells for Parkinson's disease management: Challenges, nanobased support, and prospects

T Oz, A Kaushik, M Kujawska - World Journal of Stem Cells, 2023 - ncbi.nlm.nih.gov
… Application of nanomaterials in stem cell therapy of Parkinson’s disease. Preoperative …
addressing the limitations of cell-based therapy for Parkinson’s disease. Moreover, “intelligent” …

[HTML][HTML] Current status and future perspectives on stem cell-based therapies for Parkinson's disease

Y Cha, TY Park, P Leblanc, KS Kim - Journal of Movement …, 2023 - ncbi.nlm.nih.gov
… In this review, we will discuss the prospects and challenges of hPSC-based cell therapy for
… Comparison of potential cell sources for cell replacement therapy for Parkinson’s disease (PD…

Glucocerebrosidase in Parkinson's disease: insights into pathogenesis and prospects for treatment

AHV Schapira, D Chiasserini, T Beccari… - Movement …, 2016 - Wiley Online Library
… 2016 International Parkinson and Movement Disorder Society Of all of the major
neurodegenerative diseases, Parkinson's disease (PD) has been demonstrated most clearly to have …

Premotor Parkinson's disease: clinical features, detection, and prospects for treatment

A Siderowf, MB Stern - Annals of Neurology: Official Journal of …, 2008 - Wiley Online Library
… We have proposed the term Parkinson's Disease at Risk Syndrome (PARS) to refer to
individuals who have markers that place them at a high risk for development of PD, but do not yet …

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects

M Picillo, M Moccia, E Spina, P Barone… - … of Parkinsonism and …, 2016 - Taylor & Francis
… progression of a disease as well as evaluating the response to disease-modifying treatments.
Currently, there is no biomarker fulfilling all such ideal criteria for Parkinson’s disease (PD)…

Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough

AE Lang, JA Obeso - The Lancet Neurology, 2004 - thelancet.com
… Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the
drug is complicated by a wide range of adverse effects, most notably motor fluctuations and …