[图书][B] Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects

T Nagatsu, M Sawada - 2007 - Springer
Parkinson’s disease (PD) have greatly contributed to our understanding of the molecular
pathogenesis of this disease… historical development and future prospects of biochemical studies …

Parkinson's disease treatment: Past, present, and future

JD Elsworth - Journal of neural transmission, 2020 - Springer
… treatments for Parkinson’s disease patients are reviewed, which form the foundation for an
evaluation of future options to control symptoms and halt progression of the disease. These …

Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell–derived neural progenitor cells

R Ambasudhan, N Dolatabadi, A Nutter… - Journal of …, 2014 - Wiley Online Library
… This study raises the exciting prospect of clinical translation of these approaches if acceptable
levels of efficacy and toxicity can be established. Interestingly, robust outgrowth of fibers …

The history of Parkinson's disease: early clinical descriptions and neurological therapies

CG Goetz - Cold Spring Harbor perspectives in …, 2011 - perspectivesinmedicine.cshlp.org
… internationally about Parkinson's disease. He separated Parkinson's disease from multiple
sclerosis … Early treatments of Parkinson's disease were based on empirical observation, and …

Transcriptome profiling in Parkinson's leukocytes: from early diagnostics to neuroimmune therapeutic prospects

A Simchovitz, L Soreq, H Soreq - Current Opinion in Pharmacology, 2016 - Elsevier
Parkinson's disease (PD) involves motor symptoms reflecting the progressive degeneration
of dopaminergic neurons in the substantia nigra. However, diagnosis is only enabled late in …

Reinforcing mitochondrial functions in aging brain: An insight into Parkinson's disease therapeutics

G Chandra, RA Shenoi, R Anand, U Rajamma… - Journal of chemical …, 2019 - Elsevier
… Deterioration of mitochondrial functions has been widely reported in normal aging as well
as in a spectrum of age-associated neurological diseases, including Parkinson’s disease (PD)…

Strategies for the treatment of Parkinson's disease: beyond dopamine

A Iarkov, GE Barreto, JA Grizzell… - Frontiers in aging …, 2020 - frontiersin.org
… well as new and prospective therapies for the disease. The current data suggest that prevention
or early treatment of PD may be the most effective therapeutic strategy. New advances in …

Prospects for Slowing the Progression of Parkinson's Disease

K Marek - From Neuroscience To Neurology, 2005 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting in severe
disability for people with the disease, unrelenting hardship for family members and caregivers, …

Present and future drug treatment for Parkinson's disease

AHV Schapira - Journal of Neurology, Neurosurgery & Psychiatry, 2005 - jnnp.bmj.com
… , and assess the prospects for disease modification. Surgical therapies are not considered.
… 23 showed the use of levodopa increased Unified Parkinson Disease Rating Scale (UPDRS) …

Alzheimer's and Parkinson's disease therapies in the clinic

P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
… current clinically approved therapies. To gain a … therapies, and Section 7 discusses novel
preclinical strategies. Finally, we conclude the article in Section 8 detailing the future prospects