Progress in dopaminergic cell replacement and regenerative strategies for Parkinson's disease

W Chen, Q Huang, S Ma, M Li - ACS Chemical Neuroscience, 2018 - ACS Publications
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder symptomatically
characterized by resting tremor, rigidity, bradykinesia, and gait impairment. These motor …

Potential applications of nanotechnologies to Parkinson's disease therapy

, … for Neurodegenerative Diseases Study Group of … - Parkinsonism & related …, 2008 - Elsevier
Nanotechnology will play a key role in developing new diagnostic and therapeutic tools. …
All of them are relevant to improve current therapy of Parkinson's disease (PD). …

Mesenchymal stem cells-derived exosomes: a new possible therapeutic strategy for Parkinson's disease?

H Vilaça-Faria, AJ Salgado, FG Teixeira - Cells, 2019 - mdpi.com
… Described by James Parkinson in 1817, Parkinson’s disease (PD) is the second most
common chronic neurodegenerative disease in the world, affecting over 10 million people, and …

Parkinson's disease: from pathogenesis to pharmacogenomics

R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
… From a therapeutic perspective, the introduction of levodopa (l-DOPA) in the 1960s … it
continues to be the most effective symptomatic therapy in Parkinsonian disorders [15]. However, the …

Novel pharmacological targets for the treatment of Parkinson's disease

AHV Schapira, E Bezard, J Brotchie, F Calon… - Nature reviews Drug …, 2006 - nature.com
… However, Parkinson's disease involves degeneration of non-dopaminergic … for Parkinson's
disease, and also for the motor complications that arise from the use of existing therapies. …

[HTML][HTML] Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects

B Tong, Y Ba, Z Li, C Yang, K Su, H Qi, D Zhang… - … of Disease, 2024 - Elsevier
… of Alzheimer's disease and Parkinson's disease and demonstrates the potential of
developing relevant therapeutic strategies based on lipid metabolism as a breakthrough point. …

Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection

SV More, DK Choi - Molecular neurodegeneration, 2015 - Springer
Parkinson’s disease (PD) is a slow insidious neurological disorder characterized by a loss of
dopaminergic neurons in the midbrain. Although several recent preclinical advances have …

The future of stem cell therapies for Parkinson disease

M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020 - nature.com
… replacement therapies have long been an attractive prospect for treating Parkinson disease.
… -derived cell transplants in individuals with Parkinson disease have been variable, in part …

[HTML][HTML] Cell replacement therapy for Parkinson's disease

R Wijeyekoon, RA Barker - … Acta (BBA)-Molecular Basis of Disease, 2009 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the degeneration
of dopaminergic neurons projecting from the substantia nigra to the striatum is a key …

Levodopa therapy for Parkinson disease: a look backward and forward

PA LeWitt, S Fahn - Neurology, 2016 - AAN Enterprises
… Although levodopa is widely recognized as the most effective therapy for Parkinson disease
(PD), its introduction 5 decades ago was preceded by several years of uncertainty and …