Potential therapeutic targets for Parkinson's disease

J Stoessl - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Background: Parkinson's disease is a common disorder that becomes more prevalent with
advanced age. The cardinal features are related to dopamine deficiency, arising from loss of …

Mitochondria: a therapeutic target for Parkinson's disease?

Y Luo, A Hoffer, B Hoffer, X Qi - International journal of molecular sciences, 2015 - mdpi.com
… pathogenesis of PD, therapeutics targeting mitochondria have been … targets for the
development of therapeutic approaches for treatment of PD. Here, we summarize reported …

Neurotrophic factors as a therapeutic target for Parkinson's disease

JR Evans, RA Barker - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
… before we conclude with a discussion of the potential of NTFs as a therapeutic target in PD.
… it a more attractive therapeutic target in PD, one with the ability perhaps to target both motor (…

Current and emerging therapeutic targets for Parkinson's disease

T Pingale, GL Gupta - Metabolic Brain Disease, 2021 - Springer
… models, the safety issue of these targets needs to be analyzed before entering into the
clinical trial phase. Moreover, the novel therapeutic targets discussed in the current review offer …

The parkin protein as a therapeutic target in Parkinson's disease

KF Winklhofer - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
Parkinson's disease (PD) is the most common movement disorder and the second most common
neurodegenerative disease after Alzheimer's disease… an attractive target for therapeutic

α-Synuclein: A therapeutic target for Parkinson's disease?

KA Maguire-Zeiss - Pharmacological research, 2008 - Elsevier
… both familial forms of the disease and animal models places … disease is currently without a
cure and most therapies target … in disease pathogenesis and as a potential therapeutic target

PPAR: a therapeutic target in Parkinson's disease

RK Chaturvedi, MF Beal - Journal of neurochemistry, 2008 - Wiley Online Library
Parkinson’s disease (PD) is a progressive and chronic neurodegenerative disorder,
characterized by progressive loss of dopaminergic neurons in substantia nigra. The etiology and …

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

A Cuadrado, P Moreno-Murciano… - … on therapeutic targets, 2009 - Taylor & Francis
… in the etiopathology of Parkinson's disease (PD) and as a result new therapeutic targets for
… 2 (Nrf2), as a pharmacological target for neuroprotective therapy in PD. Data generated by …

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
targets for PD and even other neurodegenerative diseases. A … and help to establish effective
therapeutic strategies. In this review, … therapeutic interventions targeting neuroinflammation. …

Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease

G Wang, J Pan, SD Chen - Progress in neurobiology, 2012 - Elsevier
Complex molecular mechanisms underlying the pathogenesis of Parkinson's disease (PD)
are gradually being elucidated. Accumulating genetic evidence implicates dysfunction of …