The 'magic'of L-dopa: why is it the gold standard Parkinson's disease therapy?

NB Mercuri, G Bernardi - Trends in pharmacological sciences, 2005 - cell.com
… The chronic treatment of Parkinson's disease with l-dopa is often … treatment of the slowness
of movement, increased muscle tone, and tremor that are typical of Parkinson's disease. Why …

Limitations of current Parkinson's disease therapy

O Rascol, P Payoux, F Ory, JJ Ferreira… - … Association and the …, 2003 - Wiley Online Library
… L-Dopa remains the gold standard for the treatment of PD because of its impressive efficacy
on the motor symptoms of parkinsonism and because of its relatively cheap price. When …

Treatment strategies for Parkinson's disease

H Yuan, ZW Zhang, LW Liang, Q Shen… - Neuroscience …, 2010 - ncbi.nlm.nih.gov
… However, currently, drug therapy cannot completely cure the disease. DA replacement
therapy with levodopa (L-Dopa), although still being a gold standard for symptomatic treatment of …

A comprehensive approach to care in Parkinson's disease adds quality to the current gold standard

CP Vaughan, LP Prizer, AE Vandenberg… - Movement disorders …, 2017 - Wiley Online Library
… , and (10) a review of PD medical and surgical treatments. Motor scores for the Unified
Parkinson's Disease Rating Scale (UPDRS) were collected for each patient. Individual item …

Diagnosis and management of Parkinson's disease

A Tarakad, J Jankovic - Seminars in neurology, 2017 - thieme-connect.com
… specific and sensitive biomarkers, the diagnosis of Parkinson's disease (PD) is still based on
… Levodopa therapy remains the gold standard in the management of motor features of PD. …

Validation of a sensor-based gait analysis system with a gold-standard motion capture system in patients with Parkinson's disease

V Jakob, A Küderle, F Kluge, J Klucken, BM Eskofier… - Sensors, 2021 - mdpi.com
Parkinson’s Disease Multidisciplinary Complex Treatment” program in which pharmacological
treatment … , occupational therapy, speech and language therapy, specialized balance and …

Recent advances in drug therapy for parkinson's disease

H Murakami, T Shiraishi, T Umehara, S Omoto… - Internal …, 2023 - jstage.jst.go.jp
… the 1960s, and levodopa was developed as a drug that improves both the symptoms and
life prognosis of patients (1). This drug is still the gold standard for treating PD. However, by the …

Milestones in Parkinson's disease therapeutics

O Rascol, A Lozano, M Stern, W Poewe - Movement disorders, 2011 - Wiley Online Library
… in advanced Parkinson's disease. In the early 2010s, levodopa remains the gold standard. …
door for novel nondopaminergic approaches of Parkinson's disease therapy. More recently, …

Biomarkers in Parkinson's disease

JC Morgan, SH Mehta, KD Sethi - Current neurology and neuroscience …, 2010 - Springer
therapeutic interventions. To date, clinical assessment remains the gold standard in the
diagnosis of Parkinson’s disease … rate of clinical decline in Parkinson disease. Arch Neurol 2009; …

Domperidone in Parkinson's disease: a perilous arrhythmogenic or the gold standard?

U Lertxundi, S Domingo-Echaburu… - Current drug …, 2013 - ingentaconnect.com
… the gold standard for treating gastrointestinal symptoms in patients with Parkinsons disease
(PD) because the risk of developing extrapyramidal adverse effects is considered minimal. …