The ongoing pursuit of neuroprotective therapies in Parkinson disease

D Athauda, T Foltynie - Nature Reviews Neurology, 2015 - nature.com
… Incomplete understanding of the pathogenesis of Parkinson disease (PD), … development of
effective neuroprotective therapies for PD … and testing of effective disease-modifying therapies

Neuroprotective therapy in Parkinson disease

S Chen, W Le - American journal of therapeutics, 2006 - journals.lww.com
… a remarkable progress in our understanding of the biology of Parkinson disease (PD), which
has been translated into searching for novel therapy for PD. Much focus is shifted from the …

Neuroprotective therapy for Parkinson's disease

WC Koller - Experimental neurology, 1997 - Elsevier
… in Parkinson's disease. … therapeutic intervention in Parkinson's disease. Current data suggest
that oxidative stress may play a prominent role in the pathogenesis of Parkinson's disease. …

Neuroprotective and therapeutic strategies against Parkinson's disease: recent perspectives

S Sarkar, J Raymick, S Imam - International journal of molecular sciences, 2016 - mdpi.com
… Progress in neuroprotective therapy has been hindered partly … allow us to detect early
disease symptoms. Moreover, the … is pertinent for the development neuroprotective therapies. …

Neuroprotection in Parkinson disease

N Simpkins, J Jankovic - Archives of internal medicine, 2003 - jamanetwork.com
therapy, which is designed to merely ameliorate the clinical features of the illness, the goal
of neuroprotective therapy is … If effective, neuroprotective therapy is expected to slow or even …

Obstacles to the development of a neuroprotective therapy for Parkinson's disease

F Stocchi, CW Olanow - Movement disorders, 2013 - Wiley Online Library
… trial methodology that have begun to overcome these obstacles and to improve the prospect
that we will be able to develop a neuroprotective therapy for PD in the foreseeable future. …

Pharmacological therapy in Parkinson's disease: focus on neuroprotection

ZT Kincses, L Vecsei - CNS neuroscience & therapeutics, 2011 - Wiley Online Library
therapeutic approaches in Parkinson's disease (PD) is steadily increasing the search for
effective neuroprotectivetherapies were implicated to be neuroprotective, and promising novel …

Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions

AHV Schapira, CW Olanow - Jama, 2004 - jamanetwork.com
Parkinson disease (provided courtesy of and with permission from Ken Marek, MD). Note that
in Parkinson disease… aimed at detecting neuroprotection in Parkinson disease and address …

Therapeutic prospects for Parkinson disease

CW Olanow, AHV Schapira - Annals of neurology, 2013 - Wiley Online Library
… possible targets for neuroprotective therapies. The proposed … a neuroprotective therapy for
Parkinson disease including: (1) … disease suggests novel targets for putative neuroprotective

Trial designs used to study neuroprotective therapy in Parkinson's disease

AE Lang, E Melamed, W Poewe… - Movement …, 2013 - Wiley Online Library
therapeutic needs in Parkinson's disease (PD) is the development of effective disease-modifying
or neuroprotective therapy… necessarily identical; neuroprotection implies an intervention …