Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
… , CD4 + T lymphocytes are rapidly activated to become pathogenic T helper (Th) 1 cells and
… The cytokine environment induces inflammatory CD14 + CD16 + monocytes with a high …

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

Y Zhou, B Fu, X Zheng, D Wang, C Zhao, Y Qi, R Sun… - biorxiv, 2020 - biorxiv.org
… Our results demonstrate that excessive non-effective host immune responses by pathogenic
T cells and inflammatory monocytes may associate with severe lung pathology. Therefore, …

Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of Tcell responses

F Geissmann, C Auffray, R Palframan… - Immunology and cell …, 2008 - Wiley Online Library
… directly bring blood monocytes close to naive T cells at the time and place of T-… Pathogen
are digested, processed and presented to T cells as antigenic peptide, either by monocyte

Glucose metabolism in T cells and monocytes: new perspectives in HIV pathogenesis

CS Palmer, CL Cherry, I Sada-Ovalle, A Singh… - …, 2016 - thelancet.com
… immune activation and inflammation in HIV- … host cells. Finally, we discuss how redox
signaling mediated by oxidative stress may regulate metabolic responses in T cells and monocytes

A rapid crosstalk of human γδ T cells and monocytes drives the acute inflammation in bacterial infections

M Eberl, GW Roberts, S Meuter, JD Williams… - … Pathogens, 2009 - journals.plos.org
… of Vγ9/Vδ2 T cells and monocytes in response to pathogens is of … T cells and monocytes in
the presence of microbes, leading to highly activated γδ T cells on one hand, and to monocyte

Inflammatory monocytes and the pathogenesis of viral encephalitis

RL Terry, DR Getts, C Deffrasnes… - Journal of …, 2012 - Springer
… of inflammatory monocyte trafficking to the brain and addresses the role of these cells in viral
… engage in a number of potent effector functions including antigen presentation and T cell

Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA)

BR Yoon, SJ Yoo, YH Choi, YH Chung, J Kim, IS Yoo… - PloS one, 2014 - journals.plos.org
… studies that inflammatory monocytes influence T cell polarization and expansion and shape
T-cell … To explore a pathogenic role of synovial monocytes in RA patients, we evaluated the …

[HTML][HTML] Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis

…, E Donders, R Schepers, T Van Brussel… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
… the T-cell response, we subclustered all 65,293 T cells and … pathogenic T H17.1 cells and
pro-inflammatory monocytes. … therapy tackles monocyte-mediated tissue inflammation, and …

[PDF][PDF] T-lymphocytes and monocytes in atherogenesis

G Schmitz, AS Herr, G Rothe - Herz, 1998 - academia.edu
Tcells by 10 to 50 : 1 and CD4 + T-cells ate more than twice as frequent as CD8+ celts. The
CD4 + T-cells ate memory cells, … CD4 + T-lymphocytes contribute to the pathogenesis of early …

Monocyte-mediated defense against microbial pathogens

NV Serbina, T Jia, TM Hohl, EG Pamer - Annu. Rev. Immunol., 2008 - annualreviews.org
… upregulate CD11c and MHC class II and migrate to draining lymph nodes, where they can
promote T cell proliferation, suggesting that this monocyte subset differentiates into DCs (16). …