[HTML][HTML] Myostatin as a biomarker of muscle wasting and other pathologies-state of the art and knowledge gaps

J Baczek, M Silkiewicz, ZB Wojszel - Nutrients, 2020 - mdpi.com
… of looking for a valid muscle wasting biomarker. Myostatin, a muscle mass negative regulator,
… the potential of myostatin as a biomarker of muscle wasting. Based on the literature review, …

Muscle wasting in disease: molecular mechanisms and promising therapies

S Cohen, JA Nathan, AL Goldberg - Nature reviews Drug discovery, 2015 - nature.com
… activin A, also trigger muscle protein loss in various catabolic states via the activation of …
Despite these complex pathological findings, accelerated protein degradation by activation …

Therapeutic approaches for muscle wasting disorders

GS Lynch, JD Schertzer, JG Ryall - Pharmacology & therapeutics, 2007 - Elsevier
Muscle wasting and weakness are common in many disease states and conditions
including aging, cancer cachexia, sepsis, denervation, disuse, inactivity, burns, HIV-acquired …

Muscle wasting: an overview of recent developments in basic research

S Palus, S von Haehling, J Springer - … of cachexia, sarcopenia and muscle, 2014 - Springer
… Interestingly, some chemotherapeutic drugs state weight loss as side effects, eg, the mTOR
… It has been proposed that serological peptide biomarkers whose tissue and pathology

Oxidative stress, chronic disease, and muscle wasting

JS Moylan, MB Reid - Muscle & Nerve: Official Journal of the …, 2007 - Wiley Online Library
… whether muscle wasting manifests in a diabetic state. … with muscle wasting that is evident
prior to the onset of liver disease. In a study of 250 alcoholics, 46% exhibited muscle pathology

Muscle wasting diseases: novel targets and treatments

R Furrer, C Handschin - Annual review of pharmacology and …, 2019 - annualreviews.org
Muscle wasting is observed in a variety of pathologies such as cancer, chronic kidney disease,
… used to treat aspects of proteostasis and the current state of knowledge are summarized. …

Calpains in muscle wasting

M Bartoli, I Richard - The international journal of biochemistry & cell biology, 2005 - Elsevier
… Both in genetically modified conditions and in physiological or pathological models, it has
never been possible to observe an increase in calpain 3 activity in relation to muscle wasting. …

[HTML][HTML] Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

K Lenk, G Schuler, V Adams - Journal of cachexia, sarcopenia and muscle, 2010 - Springer
… there are two pathologies of muscle wasting which are of … Oxidative stress is a state wherein
the normally well-balanced … muscle cells into a catabolic state leading to muscle wasting [40–…

Muscle type and fiber type specificity in muscle wasting

S Ciciliot, AC Rossi, KA Dyar, B Blaauw… - The international journal …, 2013 - Elsevier
Muscle wasting also leads to an increased proportion of … , indicative of muscle fibers in a
transitional state, increase after … a mild pathological phenotype in most skeletal muscles, except …

Acute skeletal muscle wasting in critical illness

ZA Puthucheary, J Rawal, M McPhail, B Connolly… - Jama, 2013 - jamanetwork.com
… , or had a primary neuromuscular pathology or … state and severity preclude the dissection
of the effect of paralysis per se or its cumulative effect with corticosteroids on muscle wasting