S Cohen, JA Nathan, AL Goldberg - Nature reviews Drug discovery, 2015 - nature.com
… activin A, also trigger muscle protein loss in various catabolic states via the activation of … Despite these complex pathological findings, accelerated protein degradation by activation …
… Musclewasting and weakness are common in many disease states and conditions including aging, cancer cachexia, sepsis, denervation, disuse, inactivity, burns, HIV-acquired …
S Palus, S von Haehling, J Springer - … of cachexia, sarcopenia and muscle, 2014 - Springer
… Interestingly, some chemotherapeutic drugs state weight loss as side effects, eg, the mTOR … It has been proposed that serological peptide biomarkers whose tissue and pathology …
JS Moylan, MB Reid - Muscle & Nerve: Official Journal of the …, 2007 - Wiley Online Library
… whether musclewasting manifests in a diabetic state. … with musclewasting that is evident prior to the onset of liver disease. In a study of 250 alcoholics, 46% exhibited musclepathology …
R Furrer, C Handschin - Annual review of pharmacology and …, 2019 - annualreviews.org
… Musclewasting is observed in a variety of pathologies such as cancer, chronic kidney disease, … used to treat aspects of proteostasis and the current state of knowledge are summarized. …
M Bartoli, I Richard - The international journal of biochemistry & cell biology, 2005 - Elsevier
… Both in genetically modified conditions and in physiological or pathological models, it has never been possible to observe an increase in calpain 3 activity in relation to musclewasting. …
K Lenk, G Schuler, V Adams - Journal of cachexia, sarcopenia and muscle, 2010 - Springer
… there are two pathologies of musclewasting which are of … Oxidative stress is a state wherein the normally well-balanced … muscle cells into a catabolic state leading to musclewasting [40–…
S Ciciliot, AC Rossi, KA Dyar, B Blaauw… - The international journal …, 2013 - Elsevier
… Musclewasting also leads to an increased proportion of … , indicative of muscle fibers in a transitional state, increase after … a mild pathological phenotype in most skeletal muscles, except …
… , or had a primary neuromuscular pathology or … state and severity preclude the dissection of the effect of paralysis per se or its cumulative effect with corticosteroids on musclewasting…