… effects of this new NLRP3 inflammasome inhibitor in the CRND8 APP Tg mouse model. …
Given that we demonstrated the activation of NLRP3 inflammasome in the TgCRND8 mice, we …

… pathology in mice 3 , the precise effect on tau pathology remains unknown. Here we show that
loss of NLRP3 inflammasome … NLRP3 activation upstream of tau pathology in Tau22 mice. …

… NLRP3 inflammasome plays an important role in host immune response to SARS-CoV-2
invasion. SARS-CoV-2 infection induced NLRP3 inflammasome … of NLRP3 inflammasome by …

… /caspase-1 axis in the pathogenesis of Alzheimer’s disease, and suggest that NLRP3
inflammasome inhibition represents a new therapeutic intervention for the disease. …

… on public health, such as metabolic pathologies (obesity, type 2 … the NLRP3 inflammasome
role in these pathologies and … to stimulate the mouse NLRP3 inflammasome, producing IL-1β …

… pathology were assessed by IHC and immunofluorescence. Our results show that NLRP3
inflammasome inhibition via NLRP3 … nigral pathological α-synuclein formation in PD mice. …

… role of NLRP3 in host defense, NLRP3 inflammasome has been … Mice lacking NLRP3,
ASC or caspase-1 clearly showed an … Thus, mice with Nlrp3 deletion had improved metabolic …

… of NLRP3 deficient mice with tauP301S (PS19) transgenic mice. In this model we studied
non-seeded tau pathology … tau pathology and its propagation, using NLRP3 knockout mice and …

… BV2 microglia and mouse primary neurons. Furthermore, we focused on the role of NLRP3
inflammasome in the function of neurons and the expression of AD pathological indicators. …

… NLRP3 inflammasome in PM 2.5 -induced cardiac functional and pathological injury in mice…
Next step, NLRP3 activation inhibitor or NLRP3 −/− mice will be used to verify our findings. …