Sepsis: The evolution in definition, pathophysiology, and management

B Gyawali, K Ramakrishna… - SAGE open …, 2019 - journals.sagepub.com
… significant evolution in the definition and management of sepsis over the last three decades.
This is driven in part due to the advances made in our understanding of its pathophysiology. …

The pathophysiology of sepsis—2021 update: Part 1, immunology and coagulopathy leading to endothelial injury

J Jacobi - American Journal of Health-System Pharmacy, 2022 - academic.oup.com
… , it should be viewed as preliminary information based on an evolving understanding. …
Cytokine storm is a potential concern in patients with COVID-19, but the cytokine and inflammatory …

Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology

M Wang, F Yu, W Chang, Y Zhang, L Zhang… - Frontiers in …, 2023 - frontiersin.org
… SARS-CoV-2 has evolved a multitude of mechanisms to interfere with inflammasome activity.
… inflammation, is deemed as a pathophysiological feature of the cytokine storm (133). It has …

The growth factor/cytokine midkine may participate to cytokine storm and contribute to the pathogenesis of SARS-CoV-2 infected patients

S Ketenci, Ş Aynacıoğlu - Authorea Preprints, 2021 - techrxiv.org
… contributes to several pathophysiological changes in the … cytokines and creation of cytokine
storm on the infection region, hypoxia triggered simultaneously several pathophysiological

Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review

Y Zhu, L Sharma, D Chang - Frontiers in Immunology, 2023 - frontiersin.org
… The rapid spread of the virus allowed the virus to evolve quickly to become more infectious.
… Here we describe major approaches to reduce the cytokine storm to alleviate the disease …

Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive …

V D'Onofrio, L Keulen, A Vandendriessche, J Dubois… - Scientific Reports, 2022 - nature.com
… The WHO defines different COVID-19 disease stages in which the pathophysiological
These are pro-inflammatory cytokines, typically seen during cytokine storm and related to …

Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy

N Matsuda, Y Hattori - Journal of pharmacological sciences, 2006 - jstage.jst.go.jp
Cytokine storms have potential to do significant damage to body tissues and organs. If a
cytokine stormEvolving concepts in the pathogenesis of post injury multiple organ failure. Surg …

[HTML][HTML] Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection

AE Cirstea, RL Buzulică, D Pirici… - Romanian Journal of …, 2020 - ncbi.nlm.nih.gov
… , cytokine storm has … evolution to sever deadly evolution. We emphasize the importance of
the autopsy, as HP findings could play an important role in understanding the pathophysiology

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - Seminars in …, 2020 - Springer
… of immune response to the virus, which results in a cytokine storm, with activation of the IL-6
signaling pathway. The pathophysiology of SARS-CoV-2 infection has strong similarities to …

The evolution of blood cell phenotypes, intracellular and plasma cytokines and morphological changes in critically ill COVID-19 patients

E Berghäll, M Hultström, R Frithiof, M Lipcsey… - Biomedicines, 2022 - mdpi.com
… immune cells has been suggested to be of pathophysiologic and prognostic value. Early in
the … The inflammatory effect caused by mastcells (MCs) is prominent in cytokine storm caused …