Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease

MK Vakil, Y Mansoori, GRL Al‐Awsi… - Journal of Medical …, 2022 - Wiley Online Library
… or initiate devastating cytokine storms which poses severe … -19 severity and pathophysiology.
Gene polymorphisms such … natural killer cells participating in a cytokine storm. Moreover, …

[HTML][HTML] COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
… pro-inflammatory cytokines, referred to as cytokine storm. Interleukins… Cytokine storm is
defined as acute overproduction and … In other words, the pathophysiological hallmark of COVID is …

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, CC Bortolasci, BK Puri, L Olive, W Marx… - Life sciences, 2020 - Elsevier
… a source of proinflammatory cytokines and reactive oxygen species (… cytokine storm and
ARDS. Pulmonary activated platelets are also an important source of proinflammatory cytokines

Brain dysfunction in COVID‐19 and CAR‐T therapy: cytokine storm‐associated encephalopathy

U Pensato, L Muccioli, I Cani, D Janigro… - Annals of Clinical …, 2021 - Wiley Online Library
… The overwhelming wave of neurological complications observed during COVID-19 pandemic
warrants an unmet need to understand the underlying pathophysiological mechanisms to …

[HTML][HTML] COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
… plays a central role in the syndrome's pathophysiology (8). Sepsis is strongly time-dependent,
and it is known that the levels of inflammation biomarkers are prone to change abruptly. …

Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management

SR Savla, KS Prabhavalkar, LK Bhatt - Expert review of anti …, 2021 - Taylor & Francis
… release of pro-inflammatory mediators (cytokine storm). Recent studies propose an active …
There are many points in the pathophysiology of SARS-CoV-2 infection, from initial infection …

[HTML][HTML] Hypoxemia and cytokine storm in COVID-19: clinical implications

C Machado-Curbelo, A González-Quevedo - MEDICC review, 2022 - SciELO Public Health
cytokine storm pathogenesis is multifactorial, we hypothesize there is a close association
between hypoxemia and cytokine storms … Functional pathophysiology of SARS-CoV-2 induced …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
… Our understanding of the pathophysiology of SARS-CoV-2 infection and CSs has been aided
by clinical and fundamental research studies. Although it is known that COVID-19 infection-…

[HTML][HTML] How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
… that IL-6 inhibitors including TCZ could mitigate cytokine stormsIL-6 inhibitors could
suppress cytokine storms in patients after CAR-T cell therapy most likely did so by blocking the IL-6

Cytokine dysregulation as a mechanism of graft versus host disease

JLM Ferrara - Current opinion in immunology, 1993 - Elsevier
… We have recently put forward the proposal that the pathophysiology of acute GVHD can be
considered a ‘cytokine storm’ [l==]. We envisage this storm as having three parts (Fig. 1). First…