[HTML][HTML] A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19

H Mashayekhi-Sardoo, H Hosseinjani - Journal of Basic and Clinical …, 2022 - degruyter.com
… ) pathway, we decided to review the previous data regarding the therapeutic effect of mTOR
inhibitor drugs in COVID-19 … The findings of the current study confirmed that mTOR inhibitor

[HTML][HTML] COVID-19 revisiting inflammatory pathways of arthritis

G Schett, B Manger, D Simon, R Caporali - Nature Reviews …, 2020 - nature.com
inhibition in the treatment of COVID-19. Despite these similarities, COVID-19 and other zoonotic
coronavirus-… COVID-19 pandemic on the treatment of patients with rheumatic diseases. …

[HTML][HTML] Activation of sphingomyelinase-ceramide-pathway in COVID-19 purposes its inhibition for therapeutic strategies

M Abusukhun, MS Winkler, S Pöhlmann… - Frontiers in …, 2021 - frontiersin.org
… Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. …
-ceramide pathway in 23 intensive care patients with severe COVID-19. We observed an …

[HTML][HTML] Host directed therapies: COVID-19 and beyond

D Tripathi, M Sodani, PK Gupta, S Kulkarni - Current Research in …, 2021 - Elsevier
… directed therapies (HDTs) effective against viral infections with a special focus on COVID-19
-2 replication, which was confirmed with low viral load in the presence of pathway inhibitors. …

[HTML][HTML] Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
… By inhibiting the Janus kinase (JAK)-signal transducer and activator of transcription (JAK-STAT)
pathway, JAK inhibitors are hypothesized to play a role in the management of CRS in …

[HTML][HTML] Possible therapeutic use of natural compounds against COVID-19

N Khan, X Chen, JD Geiger - Journal of cellular signaling, 2021 - ncbi.nlm.nih.gov
… and mTOR signaling pathways might provide therapeutic relief against COVID-19. Here, we
inhibit SARS-CoV-2 infectivity and thereby might be repurposed for use against COVID-19. …

[HTML][HTML] Shufeng Jiedu, a promising herbal therapy for moderate COVID-19: Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a …

XIA Lu, SHI Yujing, SU Jie, T Friedemann… - Phytomedicine, 2021 - Elsevier
… of action of SFJDC as a potential drug for the treatment of COVID-19. Furthermore, the
study should determine the clinical effectiveness of SFJDC for the treatment of COVID-19. …

Statin therapy in COVID-19 infection: much more than a single pathway

M Bifulco, P Gazzerro - European Heart Journal-Cardiovascular …, 2020 - academic.oup.com
… with fatal prognosis in COVID-19 infection, and growing … 183 patients with confirmed
COVID-19 pneumonia in Wuhan… reduced thrombus plasminogen activator inhibitor-1 (PAI-1), …

Evidence for an ACE2-independent entry pathway that can protect from neutralization by an antibody used for COVID-19 therapy

M Hoffmann, A Sidarovich, P Arora, N Krüger… - MBio, 2022 - Am Soc Microbiol
… -CoV-2 entry into cells and its inhibition by antibodies (4), to analyze the role of amino acid
residue 484 in host cell entry and its inhibition (see material and methods in the supplement). …

Journey of remdesivir from the inhibition of hepatitis C virus to the treatment of COVID-19

T Cihlar, RL Mackman - Antiviral Therapy, 2022 - journals.sagepub.com
… Baricitinib, a JAK1/2 pathway inhibitor, was tested in a double-blind, randomized, … COVID-19
demonstrated that a short 3-day treatment with IV RDV significantly reduced COVID-19