Rationale for evaluating PDE4 inhibition for mitigating against severe inflammation in COVID-19 pneumonia and beyond

C Bridgewood, G Damiani, K Sharif, A Watad… - Israel Medical …, 2020 - air.unimi.it
COVID-19pathways with drugs that can increase the risk of infection in healthy people,
not to mention the implications of such therapy in COVID-19-induced type-1 interferon pathway

Natural products for COVID19 prevention and treatment regarding to previous coronavirus infections and novel studies

M Boozari, H Hosseinzadeh - Phytotherapy Research, 2021 - Wiley Online Library
… The COVID-19 may present with mild and moderate disease (… and treatment for COVID-19,
the first therapeutic strategy for … –7)/Mas receptor pathway was inhibited and an imbalance in …

[HTML][HTML] Thromboplasminflammation in COVID-19 coagulopathy: three viewpoints for diagnostic and therapeutic strategies

S Gando, T Wada - Frontiers in Immunology, 2021 - frontiersin.org
… is associated with increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) (89, …
pathway and inhibition of fibrinolysis by Ang II participate in thrombus formation in COVID-19

Targeting adenosinergic pathway and adenosine A2A receptor signaling for the treatment of COVID-19: a hypothesis

MA Abouelkhair - Medical Hypotheses, 2020 - Elsevier
… Here, we show how inhibition of components of the adenosinergic pathway and adenosine
signaling via A 2A R can preserve extracellular ATP, counteract with COVID-19 defensive …

Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm

N Morgulchik, F Athanasopoulou, E Chu… - Interface …, 2021 - royalsocietypublishing.org
… Small-molecule inhibitors specific to Bruton's tyrosine kinases (BTK) such as acalabrutinib
… for the treatment of COVID-19 due to their ability to inhibit B-cell signalling pathway and …

[HTML][HTML] Immune therapy, or antiviral therapy, or both for COVID-19: a systematic review

F Cantini, D Goletti, L Petrone, S Najafi Fard, L Niccoli… - Drugs, 2020 - Springer
… act via the JAK-2 and JAK-2 signal transducers with subsequent activation of STAT pathway.
Hence, JAK-inhibitors ruxolitinib and baricitinib have been employed to treat moderate-to-…

[PDF][PDF] Therapeutic options for COVID-19: a review

R Pujari, MV Thommana, BR Mercedes, A Serwat - Cureus, 2020 - cureus.com
… and the metabolic pathway has provided … COVID-19 treatment option. Currently, there are
some clinical trials focussing on stopping ACE inhibitors and ARBs for patients with COVID 19. …

[HTML][HTML] Baricitinib for COVID-19: a suitable treatment?

EG Favalli, M Biggioggero, G Maioli… - The Lancet Infectious …, 2020 - thelancet.com
… about the potential use of baricitinib for severe acute respiratory syndrome coronavirus 2 (SARS-…
therapy is an undeniable advantage over other potential inhibitors of the same pathway. …

SARS-CoV-2 and the possible role of Raf/MEK/ERK pathway in viral survival: is this a potential therapeutic strategy for COVID-19?

M Ghasemnejad-Berenji, S Pashapour - Pharmacology, 2021 - karger.com
… that the MAPK signaling pathway is involved in murine coronavirus RNA … inhibit the Raf/MEK/ERK
signaling pathway may be potential antiviral candidates for the treatment of COVID-19. …

[HTML][HTML] Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

PM George, AU Wells, RG Jenkins - The Lancet Respiratory …, 2020 - thelancet.com
pathways in … pathways in SARS-CoV-2 infection. Whether or not this speculation is confirmed,
the key conclusion from the INBUILD study was that nintedanib therapy appears to inhibit