… effects of disease and developmental changes on transporter expression and/or activity in
… of clinically relevant drug transporters in pediatric patients and altered transporter activity in …

… transporters, which are incorporated into PBPK models. Although, intrinsic clearance and
inhibition data from in vitro systems generally tend to underpredict in vivo clearance and mag…

… To enhance overall predictive performance of transporter-based PBPK models, it is … The
PBPK modeling of drug transporters is less mature than that of drug-metabolizing enzymes. This …

… However, the application of PBPK for transporter-mediated DDIs (tDDI) in drug … of PBPK
models for tDDI is not well established, here, we represent and discuss examples of PBPK …

… it is actively transported by several different drug transporters, there are DDIs described with
… -body PBPK model of rosuvastatin to support the investigation of drug-drug interactions, that …

… PBPK model predicted the highest interaction potential against liver uptake transporters, with
a … the application of PBPK modeling for quantitative prediction of transporter-mediated DDIs …

… PBPK model and reviewed PBPK applications in FIH PK prediction, enzyme- and transporter-
… , we discuss the enzyme-, and transporter-mediated DDIs involved in PBPK modeling and …

… Through quantitative assessment of the effect of OATP1B1 genetic polymorphism and
inhibitors of transporters and metabolizing enyzmes via PBPK modeling, we confirmed the …

… in drug discovery and development. In this mini-review, the concept and methodology of PBPK
modeling … Thus, additional data of transporter clearance are needed for PBPK modeling. …

… in vivo in humans, and also for the initial predictions of the potential of drug interactions [2].
We constructed a PBPK model including transporter-mediated membrane transport …