Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

G Hajishengallis, T Chavakis - Nature Reviews Immunology, 2021 - nature.com
… whereby periodontitis could initiate or aggravate a comorbid … the link between periodontitis
and comorbidities is the focus … periodontal pathogens and periodontitis-associated systemic …

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

G Hajishengallis - Periodontology 2000, 2022 - Wiley Online Library
periodontitis and inflammatory comorbidities may involve periodontitis-associated low-grade
systemic inflammation, … Conversely, systemic diseases also affect periodontitis, for instance …

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

P Holmstrup, C Damgaard, I Olsen… - Journal of oral …, 2017 - Taylor & Francis
… [OR] = 1.29) after adjustment for sex, age, and comorbidity, and that the risk increased with
increased degree of periodontal inflammation [Citation76]. Furthermore, osteoporosis was …

The role of inflammation and genetics in periodontal disease

BG Loos, TE Van Dyke - Periodontology 2000, 2020 - Wiley Online Library
… chronic inflammatory diseases, including periodontal disease.17, 18 Chronic inflammatory
diseases … Recently, the importance of the risk for cardiovascular comorbidity in patients with …

Viruses, periodontitis, and comorbidities

F Teles, RG Collman, D Mominkhan… - Periodontology …, 2022 - Wiley Online Library
… viruses and periodontal diseases is consequential rather than causal. In that case, the
rationale set forth is that the inflammation that is part of periodontal diseases pathogenesis …

Periodontal disease increases the risk for onset of systemic comorbidities in dental hospital attendees: An 18‐year retrospective cohort study

D Zhao, Z Zhen, G Pelekos, KH Yiu… - … of periodontology, 2019 - Wiley Online Library
periodontal disease experience to some extent reflects the host susceptibility to onset of
common systemic comorbidities. … that the severity of periodontal infection/inflammation may be a …

Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets

Q Wu, W Zhang, Y Lu, H Li, Y Yang, F Geng… - International …, 2024 - Elsevier
… in periodontitis and associated inflammatory comorbidities, the … immune cells in chronic
inflammatory diseases (Fig. 2). … disorders influence the development of periodontal disease. …

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

S Hobbins, ILC Chapple, E Sapey… - … pulmonary disease, 2017 - Taylor & Francis
… the hypothesis that COPD and inflammatory periodontal disease (periodontitis) could be
pathologically associated, including a review of shared inflammatory mechanisms. It highlights …

Association between periodontal disease and comorbidities in Saudi's Eastern Province

M Madi, HM Abuohashish, D Attia… - BioMed Research …, 2021 - Wiley Online Library
… is associated with multiple comorbidities that influence a … between periodontal disease and
multiple comorbidities reported … the local inflammatory response triggered in the periodontal

Association between obstructive sleep apnea and comorbidities with periodontal disease in adults

C Latorre, F Escobar, J Velosa, D Rubiano… - … of Periodontology, 2018 - journals.lww.com
… , and plasma cells into the periodontal tissue that releases cytokines, interleukins, … with
periodontal disease enter the bloodstream, elevating the levels of pro-inflammatory cytokines …