… We will apply current evidence from an animal model of DM2 and VaD to understand how
glymphatic clearance goes awry. In DM2 rats, there was a three-fold increase in residual Gd-…

… our knowledge of CNS' glymphatic drainage physiology. If this result … drainage channels
in the human glymphatic system. Would it also be possible to observe the perivascular spaces …

… in clearing brain waste and belong to the “glymphatic” system and/or the “intramural
periarterial drainage” … Related brain waste clearance systems include the blood–brain barrier, …

… , we estimated glymphatic clearance using diffusion tensor imaging along perivascular spaces,
… We additionally measured the volume of the perivascular space using T 2 -weighted MRI. …

… Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport and
glymphatic clearance … along the perivascular space indicates less activity in the glymphatic …

… fluid (CSF) moves by convection from the perivascular space (PVS) of arteries through the
extracellular space of the brain parenchyma to the PVS of veins for clearance (Iliff et al., 2012; …

… Interconnection between the subarachnoid CSF compartment and brain perivascular spaces
is reported in some animal studies, but with controversy, and in vivo CSF tracer studies in …

… amyloid deposits, and glymphatic clearance was reduced prior … glymphatic system is due
to blood components, such as fibrin and fibrinogen deposits, which occlude perivascular spaces…

… perivascular spaces and thus disrupt the glymphatic system transport. Confirmation of
such hypotheses was shown in studies on hypertensive rats (Mortensen et al. 2019). One-tissue …

… perivascular spaces in the human cerebral cortex and the basal ganglia, as perivascular
spaces … in that paper, other points can be made regarding the concept of glymphatic drainage. …