Uptake transporters in the basolateral membrane of hepatocytes … , uptake into hepatocytes
is a prerequisite for their subsequent metabolism. Therefore, alteration of uptake transporter …

… is dependent on uptake transporters expressed at the … of transporter genes, polymorphisms
in their promoter regions may affect binding of transcription factors to their response elements…

… , both genetic and environmental factors contribute to interindividual … OCT polymorphisms
have been extensively studied in the … The cation uptake transporters OCT1 and OCT3 and the …

… transporters (OAT) from the solute carrier (SLC) family play an essential role in the uptake
of … of expression and activity of these transporters translates into interindividual variability in …

… aspects of transporters associated with the cellular uptake and efflux of drugs. In addition,
we present a compilation of currently known genetic polymorphisms in drug transporters. The …

… by the uptake transporters organic cation transporter (OCT) 1 and OATP1B1 and by the
efflux transporters ABCB1, ABCC2, and ABCC3 (Fig. 2) [60, 61]. Hepatic uptake of morphine …

… is seen in the three OCT transporters and they are predicted to … histamine and serotonin
uptake by these transporters in a dose-… that transporter expression and other factors influencing …

… of the organic cation transporter (OCT) family, and the … factors can account for up to 95%
of the interindividual variability in drug disposition and effects.Emerging pharmacogenetic …

… An important aspect of modern medicine is its orientation to … OCT subfamily includes three
organic cation transporters (… Pharmacogenetic studies have shown that polymorphisms in …

… Overall, these trends and factors are driving the selection of … Unlike other OCT transporters,
OCT1 was found to be … as a hepatoselective OCT and plays a pivotal role in the uptake of …