… In this review, we described the mechanism of pharmacokinetic DDI focusing the interest
on their clinical implications, addressing the reader's attention for pharmaceutical interactions …

… the experimental level, little is known about pharmacokinetic interactions in man. How- …
drugs are doubled or halved, and there is no doubt that many other pharmacokinetic interactions …

… Drug-drug interactions-the effects of one drug on the efficacy and/or toxicity of another
drug-have become an important issue in health care. The majority of patients are treated with …

… and subsequent pharmacological/toxicological effects of their substrates (2… impact of drug
transporters on the clinical pharmacokinetics of new drug candidates in the early phase of drug …

… of pharmacokinetic drug-drug interactions reported so far have been limited to the analysis
of hepatic metabolism. However, the hepatic clearance of many drugs … drug-drug interactions …

… Because some general knowledge of drug metabolism and some specific information on
the drug-… pharmacokinetic drug-drug interactions, this review begins with a “primer” on drug …

… in drug action occur in the area of the target tissue) or pharmacokinetic (when one drug affects
… Another mechanism of drug interaction is really a pharmaceutical incompatibility when, for …

… Drug-drug interactions occur when one therapeutic agent either alters the … (pharmacokinetic
interactions) or the biological effect of another agent (pharmacodynamic interactions). …

… mic agents to anticancer drugs such as etoposide, … interaction is not well documented.
Consequently, this review article provides an overview of PGP-nmediated drug-drug interactions …

… that involve both pharmacokinetic and pharmacodynamic … a single perspective of
pharmacokinetics or pharmacodynamics, … of pharmacokinetic and pharmacodynamic interactions …