Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH

GN Ioannou, CL Horn, V Kothari, MM Yeh, I Shyu… - Journal of Lipid …, 2023 - ASBMB
… deletion or pharmacologic inhibition of the NLRP3 inflammasome on … Nlrp3 KO (expected
to inhibit the NLRP3 inflammasome) or Casp1 KO (expected to inhibit all inflammasomes) mice …

NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Z Wang, G Xu, Z Li, X Xiao, J Tang… - Journal of Inflammation …, 2022 - Taylor & Francis
inhibiting NLRP3 inflammasome activation, thus avoiding the occurrence of serious diseases.
NLRP3 inflammasome … and inhibiting the activation of NLRP3 inflammasome and NF-κB …

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

G Yang, HE Lee, JY Lee - Scientific reports, 2016 - nature.com
… of NLRP3 inflammasome activation by an orally available small molecule inhibitor leads to
the … Our results demonstrate the inhibitory effects of SFN on NLRP3 inflammasome activation …

NLRP3 inflammasome and its inhibitors: a review

BZ Shao, ZQ Xu, BZ Han, DF Su, C Liu - Frontiers in pharmacology, 2015 - frontiersin.org
… Several NLRP3 inflammasome inhibitors have been described… of activation of the NLRP3
inflammasome, its association with … the state of research into NLRP3 inflammasome inhibitors. …

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

RC Coll, AAB Robertson, JJ Chae, SC Higgins… - Nature medicine, 2015 - nature.com
inhibit the NLRP3 inflammasome. Glyburide inhibits IL-1β production at micromolar
concentrations in response to the activation of NLRP3 … again for NLRP3 mutant mice 14 d after …

A new pharmacological effect of levornidazole: inhibition of NLRP3 inflammasome activation

X Wang, S Wang, C Hu, W Chen, Y Shen, X Wu… - … Pharmacology, 2015 - Elsevier
… Therefore, we confirmed the inhibitory effect of levornidazole on NLRP3 inflammasome … the
novel pharmacological effect of levornidazole on the activation of the NLRP3 inflammasome (…

Pharmacological inhibition of the nod-like receptor family pyrin domain containing 3 inflammasome with MCC950

SE Corcoran, R Halai, MA Cooper - Pharmacological reviews, 2021 - ASPET
… This study found that NLRP3 inflammasome expression was increased in TBI, primarily in
microglia. MCC950 administration led to more favorable neurological outcomes; specifically, …

Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases

N Özenver, T Efferth - Pharmacological research, 2021 - Elsevier
inhibiting NLRP3 inflammasome in addition to NLRP3-mediated … of phytochemical inhibitors
targeting NLRP3 inflammasome … between inflammasome activation or inhibition with NLRP3

Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases

X Zhang, A Xu, J Lv, Q Zhang, Y Ran, C Wei… - European journal of …, 2020 - Elsevier
NLRP3 inflammasome was initially observed in studies employing pharmacological inhibitors
… -incubation of cells with antioxidants inhibited the activation of NLRP3 inflammasome [26]. …

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

Y Yang, H Wang, M Kouadir, H Song, F Shi - Cell death & disease, 2019 - nature.com
… Here, we discuss five recently identified pharmacological inhibitors of NLRP3 inflammasome
activation and their therapeutic potentials (Table 1). Figure 4 shows the characteristics and …