… the shared genetic basis of these eight disorders: (1) Can we identify a … psychiatric disorders?
(2) Can we detect additional loci associated with risk for multiple disorders (pleiotropic loci)…

… Pleiotropic mechanisms underlying cross-phenotype associations. We define 3 classes of
pleiotropic mechanisms: biological pleiotropy, mediated pleiotropy, and spurious pleiotropy. (A…

… 2013a, b) and among multiple immune system disorders (Cotsapas et al. 2011), separately.
… pleiotropic effects among psychiatric disorders and among immune-related disorders (Table …

… Given strong evidence of genetic correlation and genetic overlap between gastrointestinal
tract diseases and psychiatric disorders, we found that pleiotropic genetic variants, loci, and …

… of a cross-disorder GWAS meta-analysis of eight psychiatric disorders from the Psychiatric
Genomics … We identified 80 SNPs with pleiotropic effects on psychiatric disorders that show an …

… pleiotropy mapping for psychiatric disorders. First, instead considering individual SNPs, we
implemented a gene-centric pleiotropy … on summary statistics of psychiatric disorders, we first …

… independent markers associated with several traits (pleiotropy at the gene level). We also
… This study demonstrates that mental disorders and related traits do show pleiotropy at the …

… : The metaCCA method identified novel variants associated with psychiatric disorders by …
psychiatric disorders based on the pleiotropic genes and common mechanisms identified. …

… -analysis on 12 psychiatric disorders to identify pleiotropic SNPs. The meta-… psychiatric
disorders identified substantial pleiotropic overlap, but mainly among pairs of psychiatric disorders…

… of substance use and psychiatric disorders, about 50% (230 loci) were pleiotropic with
additional 111 pleiotropic loci not reported from past GWAS. Of the 341 pleiotropic loci, 152 were …