Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

DM Ruderfer, AH Fanous, S Ripke, A McQuillin… - Molecular …, 2014 - nature.com
… and SCZ, we sought to identify whether disease-specific polygenic scores of one disorder
were correlated with symptom dimensions in the other disorder. We had manic, depressive, …

Polygenic dissection of the bipolar phenotype

ML Hamshere, MC O'Donovan, IR Jones… - The British Journal of …, 2011 - cambridge.org
… To replicate the results of polygenic analyses observed in the WTCCC bipolar disorder … We
investigated the polygenic scores obtained in the UCL bipolar disorder sample. Of the 74 062 …

Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores

BJ Coombes, M Markota, JJ Mann, C Colby… - Translational …, 2020 - nature.com
polygenic contribution to the two disorders 5 . Bipolar disorder (BD) is a complex illness with
… -phenotypes often have a different course of illness, prognosis, and treatment response 6,7,…

[PDF][PDF] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes

DM Ruderfer, S Ripke, A McQuillin, J Boocock… - Cell, 2018 - cell.com
… Here, we present a genetic dissection of bipolar disorder and schizophrenia from over 100,000
genotyped … We also found polygenic components that significantly correlated from one …

The effect of polygenic risk scores for major depressive disorder, bipolar disorder and schizophrenia on morphological brain measures: a systematic review of the …

G Cattarinussi, G Delvecchio, F Sambataro… - … of affective disorders, 2022 - Elsevier
… Magnetic Resonance Imaging (MRI) studies assessing the effect of polygenic risk score (PRS)
for psychiatric disorders on brain structure show heterogeneous results. Therefore, we …

Genomic dissection of bipolar disorder and schizophrenia in 50K cases, 50K controls and 28 subphenotypes

…, Psychiatric Genomics Consortium Bipolar … - European …, 2019 - Elsevier
… Finally, we present polygenic analyses of 28 different subphenotypes demonstrating underlying
genomic components contributing to symptom dimensions such as psychotic features in …

Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores

D Lee, JH Baek, K Ha, EY Cho, Y Choi… - … of bipolar disorders, 2022 - Springer
Bipolar disorder (BD) has the greatest suicide risk among mental and physical disorders.
A … Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. …

Association of polygenic liabilities for major depression, bipolar disorder, and schizophrenia with risk for depression in the Danish population

KL Musliner, PB Mortensen, JJ McGrath… - JAMA …, 2019 - jamanetwork.com
… Genomic dissection of bipolar disorder and schizophrenia, … Polygenic liabilities for
schizophrenia and bipolar disorder were also associated with an increased hazard of depression but …

Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder

M Markota, BJ Coombes, BR Larrabee… - Translational …, 2018 - nature.com
Bipolar disorder (BD) is a highly heterogeneous illness, which presents clinical challenges
and likely … Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and …

[HTML][HTML] Polygenic risk scores and bipolar disorder

S Bengesser, E Reininghaus - Journal of Psychiatry and Brain Science, 2018 - hapres.com
… must be used to decipher the underlying disease mechanisms of Bipolar disorder.
Recently, … Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and …