Clinical use of current polygenic risk scores may exacerbate health disparities

AR Martin, M Kanai, Y Kamatani, Y Okada, BM Neale… - Nature …, 2019 - nature.com
Polygenic risk scores (PRS) are poised to improve … This disparity is an inescapable
consequence of Eurocentric … disseminated to ensure that health disparities are not increased for …

[HTML][HTML] Current clinical use of polygenic scores will risk exacerbating health disparities

AR Martin, M Kanai, Y Kamatani, Y Okada… - Nature …, 2019 - ncbi.nlm.nih.gov
Polygenic risk scores (PRS) are poised to improve … This disparity is an inescapable
consequence of Eurocentric … health disparities are not increased for those already most …

Hidden 'risk'in polygenic scores: clinical use today could exacerbate health disparities

AR Martin, M Kanai, Y Kamatani, Y Okada, BM Neale… - bioRxiv, 2018 - biorxiv.org
Current clinical use of polygenic scores will risk exacerbating health disparities | bioRxiv … ,
meaning that the accuracy of polygenic scores in different populations is highly dependent on …

[HTML][HTML] Perspective: the clinical use of polygenic risk scores: race, ethnicity, and health disparities

MC Roberts, MJ Khoury, GA Mensah - Ethnicity & disease, 2019 - ncbi.nlm.nih.gov
… use of current PRS may exacerbate health disparities.3 Studies have consistently demonstrated
… More broadly, issues of health disparities in racial and ethnic minority populations have …

Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences

NA Rosenberg, MD Edge, JK Pritchard… - … , and public health, 2019 - academic.oup.com
polygenic scores, polygenic adaptation and population differences. We show how genetic
contributions to traits, as estimated by polygenic scores, … relation to health disparities between …

Race and ethnicity stratification for polygenic risk score analyses may mask disparities in Hispanics

SL Clarke, RDL Huang, AT Hilliard, C Tcheandjieu… - Circulation, 2022 - Am Heart Assoc
Polygenic risk scores (PRSs) are central to the development … for some Hispanics, but this
disparity is masked when the … health record within a span of 12 months. Participants were …

Evaluating and improving health equity and fairness of polygenic scores

T Zhang, G Zhou, L Klei, P Liu, A Chouldechova… - Human Genetics and …, 2024 - cell.com
Polygenic scores (PGSs) are quantitative metrics for predicting phenotypic values, such
as human height or disease status. Some PGS methods require only summary statistics of a …

Polygenic scores help reduce racial disparities in predictive accuracy of automated type 1 diabetes classification algorithms

AJ Deutsch, L Stalbow, TD Majarian… - Diabetes …, 2023 - Am Diabetes Assoc
… algorithms may exacerbate health disparities because of an … Polygenic scores may be
used to improve the performance of phenotyping algorithms and potentially reduce this disparity

Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues

ACF Lewis, RC Green - Genome Medicine, 2021 - Springer
… Reducing health disparities is a key value for public health, but clinical use of PRS could
exacerbate race-based health disparities owing to differences in predictive power across …

Principles and methods for transferring polygenic risk scores across global populations

…, Polygenic Risk Methods in Diverse Populations … - Nature Reviews …, 2024 - nature.com
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human …
European genetic ancestries can increase health disparities due to poor predictive performance …