… To identify proteins other than gingipains secreted by the PorSS, we compared the
proteomes of P. … as the wild-type strain secreted gingipains that had the ability to process both …

… By comparing the wild type W50 with its gingipain deficient strains we show that cysteine
proteinases are required by P. … This study provides new insight of the pathogenesis of P. …

… in vivo, we hypothesized that Porphyromonas gingivalis, a putative periodontal pathogen
with … Gingipains are cysteine proteases produced by P. gingivalis that are either secreted or …

… Therefore, the question is, whether bacteria-secreted gingipains predominantly degrade
their membrane-anchored substrates, just cleave them at one or a very low number of sites, or …

… -gingipain (gingipain R) and Lys-gingipain (gingipain K), often abbreviated to Rgp and Kgp,
respectively. Working in concert gingipains … focus only on gingipains secretion, processing, …

… We named the gingipain secretion system the Por secretion system(PorSS). Genes encoding
PorSS proteins are conserved among a group of bacteria including periodontal pathogens …

… - and calcium-dependent neutral endopeptidases secreted by many cells as inactive
precursors (pro-MMPs) Citation[77]. The Arg- and Lys- gingipains have been reported to affect the …

… cysteine proteinases of Porphyromonas gingivalis that act as important virulence factors for
… during secretion. In this report, we describe and characterize inhibition of the gingipains by …

… In this paper we review the secretion and maturation of the gingipains on the P. gingivalis
cell surface, their role in tissue binding, disruption and acquisition of heme and peptides, their …

… Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad
range of host proteins. Inactivation of gingipains … of events in the secretion of gingipain R1 …