Over-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathway

H Wang, Y Yin, W Li, X Zhao, Y Yu, J Zhu, Z Qin… - PloS one, 2012 - journals.plos.org
… In this study, we transfected PDGFR-β into spleen-derived EPCs and found that PDGFR-β
PDGFR-β positive cells in the total cells were 88.6±4.3% (n = 5; three random fields per well)…

PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia

J Shen, Y Ishii, G Xu, TC Dang… - Journal of Cerebral …, 2012 - journals.sagepub.com
… and raise the possibility that PDGFR-β may also have a … PDGFR-β KO mice (postnatally
induced systemic KO and neuroepithelium-derived cells KO), we examined the role of PDGFR-β

Both platelet-derived growth factor receptor (PDGFR)-α and PDGFR-β promote murine fibroblast cell migration

J Yu, A Moon, HRC Kim - Biochemical and biophysical research …, 2001 - Elsevier
… -PDGFRs promote fibroblast cell migration and their effects are additive. Taken together, we
propose that cell-type specific -PDGFR signaling is critical for regulation of … both positive and …

A kt‐and E rk‐mediated regulation of proliferation and differentiation during PDGFR β‐induced MSC self‐renewal

B Gharibi, MS Ghuman… - Journal of cellular and …, 2012 - Wiley Online Library
… In addition, inhibition of PDGFR-β by a specific inhibitor (SU 16f) reduced the EdU-positive
cells by 60% (P < 0.001), suggesting that PDGF signalling is involved in normal MSC growth, …

… -derived growth factor receptor-α (PDGFR-α) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-α …

MR Bonello, LM Khachigian - Journal of Biological Chemistry, 2004 - ASBMB
PDGFR-α protein and transcriptional regulation in SMCs is under the positive regulatory
-tyrosine kinase cell surface receptors, PDGFR-α and -β. PDGFs are secreted as disulfide-…

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

S Yuzawa, MR Kano, T Einama, H Nishihara - Medical oncology, 2012 - Springer
… growth factor (PDGF) receptor β (PDGFRβ). Both are markers of … proliferation of PSCs positive
for PDGFRβ and induce PSC … , while PDGFRβ does, although both SMA and PDGFRβ are …

[HTML][HTML] PDGFRβ signaling regulates mural cell plasticity and inhibits fat development

LE Olson, P Soriano - Developmental cell, 2011 - cell.com
… identify PDGFRβ signaling as an important in vivo regulator of … through the PDGF receptor
β (PDGFRβ) expressed in mural cell … This is consistent with PDGFRβ as a positive regulator of …

PDGFR-β signaling regulates cardiomyocyte proliferation and myocardial regeneration

…, H Lian, J Pei, Y Li, X Chen, S Song, J Xia, B Zhou… - Cell reports, 2019 - cell.com
… to discover relevant regulators for CM proliferation and … positive CMs in both the remote
zone and border region and found a remarkable increase in the number of EdU-positive CMs in β

[HTML][HTML] Platelet-derived growth factor (PDGF)/PDGF receptors (PDGFR) axis as target for antitumor and antiangiogenic therapy

M Raica, AM Cimpean - Pharmaceuticals, 2010 - mdpi.com
… The crucial role of PDGF-B and PDGFR-β in angiogenesis has … PDGFRβ signaling:
transcriptional down-regulation of … , and the reaction is positive for PDGFRβ in the perivascular …

Upregulated expression of PDGF receptor beta in endocrine pancreatic tumors and metastases compared to normal endocrine pancreas

ML Fjällskog, O Hessman, B Eriksson… - Acta …, 2007 - Taylor & Francis
… cells, tumor angiogenesis and regulation of tumor interstitial fluid pressure. Development of
… As positive control for PDGFR beta we used colon cancer stroma and as negative control we …