Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

L Liu, P Wang, MS Nair, J Yu, M Rapp, Q Wang, Y Luo… - Nature, 2020 - nature.com
… We have identified a collection of SARS-CoV-2-neutralizing mAbs that are not only
potent but also diverse. Nine of these antibodies can neutralize the authentic virus in vitro at …

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

NK Hurlburt, E Seydoux, YH Wan, VV Edara… - Nature …, 2020 - nature.com
… Our structure indicates that potent neutralizing antibodies against SARS-CoV-2 bind the …
specific for SARS-CoV-2 only, thus explaining the lack of cross neutralization with SARS-CoV-1. …

Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - Immunity, 2020 - cell.com
SARS-CoV-2-S were IgG (Figures 1C and 1D). The serum from the SARS-CoV-2 infected
donor displayed potent neutralizing … expressing the S protein from SARS-CoV-2 isolate Wuhan-…

An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

E Traggiai, S Becker, K Subbarao, L Kolesnikova… - Nature medicine, 2004 - nature.com
… 1, produces an IgG1,κ neutralizing monoclonal antibody. When … neutralize SARS-CoV, the
S3.1 antibody neutralized 75 TCID 50 SARS-CoV at a concentration of ∼300 ng/ml, a potency

mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant

H Gruell, K Vanshylla, P Tober-Lau, D Hillus… - Nature medicine, 2022 - nature.com
potent neutralizing response against the Omicron variant following booster vaccination
may be a consequence of ongoing affinity maturation following initial vaccination or SARS-CoV-2 …

Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

A Gharbharan, CCE Jordans… - Nature …, 2021 - nature.com
… containing high titers of neutralizing SARS-CoV-2 antibodies, no … respiratory tract, influence
SARS-CoV-2 antibody development … of patients already had potent neutralizing SARS-CoV-2 …

Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine

Y He, Y Zhou, S Liu, Z Kou, W Li, M Farzan… - … and biophysical research …, 2004 - Elsevier
… completely inhibited SARS-CoV infection at a … potent neutralizing antibody responses and
has potential to be developed as an effective and safe subunit vaccine for prevention of SARS

Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association

J Sui, W Li, A Murakami, A Tamin… - Proceedings of the …, 2004 - National Acad Sciences
… a nanomolar affinity that potently neutralizes SARS-CoV infection and efficiently inhibits
syncytia … The approach used in our investigation is noteworthy in that a potent neutralizing high-…

[HTML][HTML] Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells

Y Cao, B Su, X Guo, W Sun, Y Deng, L Bao, Q Zhu… - Cell, 2020 - cell.com
… Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-…
+ clonotypes, 14 potent neutralizing antibodies were identified, with the most potent one, BD…

[HTML][HTML] Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

AC Walls, B Fiala, A Schäfer, S Wrenn, MN Pham… - Cell, 2020 - cell.com
potent and protective antibody responses against SARS-CoV-2 in mice. The nanoparticle
vaccines display 60 SARS-CoV-… immunogenic array and induce neutralizing antibody titers 10-…