Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

L Liu, P Wang, MS Nair, J Yu, M Rapp, Q Wang, Y Luo… - Nature, 2020 - nature.com
… that all potent SARS-CoV-2-neutralizing antibodies described to … Neutralizing antibodies
to the stem region of the S trimer … monoclonal antibodies with strong virus-neutralizing activity …

[HTML][HTML] Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells

Y Cao, B Su, X Guo, W Sun, Y Deng, L Bao, Q Zhu… - Cell, 2020 - cell.com
… Moreover, we demonstrated that SARS-CoV-2-neutralizing antibodies could be directly …
CoV-neutralizing antibodies. Altogether, we showed that human neutralizing antibodies could be …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

PJM Brouwer, TG Caniels, K van der Straten… - Science, 2020 - science.org
… to be a requirement for potent neutralization. The most potent NAbs both targeted the RBD
on … Although direct comparisons are difficult, the neutralization potency of these and several …

Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

LM Walker, SK Phogat, PY Chan-Hui, D Wagner… - Science, 2009 - science.org
… Here, we have confirmed that this region serves as a potent neutralization target and
demonstrated that antibodies that recognize conserved parts of V2 and V3 can have broad reactivity…

Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection

AI Flyak, X Shen, CD Murin, HL Turner, JA David… - Cell, 2016 - cell.com
… We isolated a large panel of human monoclonal antibodies (mAbs) against BDBV glycoprotein
(… We determined that a large proportion of mAbs with potent neutralizing activity against …

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - BioRxiv, 2020 - biorxiv.org
… main target of neutralizing antibodies. Here we describe multiple monoclonal antibodies
targeting SARS-… One antibody, named S309, potently neutralizes SARS-CoV-2 and SARS-CoV …

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

NA Doria-Rose, CA Schramm, J Gorman, PL Moore… - Nature, 2014 - nature.com
neutralization potency and breadth can be achieved without extraordinary levels of somatic
hypermutation. Although some neutralizing antibodies … HIV-1 neutralization breadth within …

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

ZA Bornholdt, HL Turner, CD Murin, W Li, D Sok… - Science, 2016 - science.org
… of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures
Neutralizing antibodies targeting this site show potent therapeutic efficacy against lethal …

Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection

R Kong, H Li, F Bibollet-Ruche, JM Decker… - Journal of …, 2012 - Am Soc Microbiol
antibody neutralization. We characterized the potency and breadth of neutralizing antibody
(… 7312A proviral backbone showed potent neutralization of all but 4 viruses. The specificity of …

[HTML][HTML] Broadly neutralizing antibodies against COVID-19

D Zhou, J Ren, EE Fry, DI Stuart - Current Opinion in Virology, 2023 - Elsevier
… Although neutralizing antibodies have been found that bind a single, so-called supersite …
and usually less potent than the best ACE2 blockers, neutralizing antibodies have also been …