Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

L Liu, P Wang, MS Nair, J Yu, M Rapp, Q Wang, Y Luo… - Nature, 2020 - nature.com
potency, with 50% virus-inhibitory concentrations of 0.7 to 9 ng ml −1 . Epitope mapping
showed that this collection of nineteen antibodies … , two other powerful neutralizing antibodies

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

TF Rogers, F Zhao, D Huang, N Beutler, A Burns, W He… - Science, 2020 - science.org
… -throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and
… We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding …

Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - Immunity, 2020 - cell.com
… the SARS-CoV-2 infected donor displayed potent neutralizing … expressing the S protein from
SARS-CoV-2 isolate Wuhan-Hu-1 (… had developed strong binding and neutralizing antibody

Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

A Gharbharan, CCE Jordans… - Nature …, 2021 - nature.com
… treatment to disentangle which COVID-19 patients may benefit … tract, influence SARS-CoV-2
antibody development or serum … already had potent neutralizing SARS-CoV-2 antibodies at …

[HTML][HTML] Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells

Y Cao, B Su, X Guo, W Sun, Y Deng, L Bao, Q Zhu… - Cell, 2020 - cell.com
… The COVID-19 pandemic urgently needs therapeutic and … rapid identification of SARS-CoV-2-neutralizing
antibodies by high-… potent neutralizing antibodies were identified, with the most …

Potently neutralizing and protective human antibodies against SARS-CoV-2

SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen… - Nature, 2020 - nature.com
… that target the spike (S) glycoprotein 5 , and identify several that exhibit potent neutralizing
… of neutralizing antibodies. Other groups have reported the selection of SARS-CoV-2 RBD …

[HTML][HTML] Human neutralizing antibodies elicited by SARS-CoV-2 infection

B Ju, Q Zhang, J Ge, R Wang, J Sun, X Ge, J Yu… - Nature, 2020 - nature.com
… We did not obtain crystal structures of two other potent neutralizing antibodies (P2C-1F11
and P2C-1A3); however, given their strong competition with P2B-2F6, it is reasonable to …

[HTML][HTML] Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

AC Walls, B Fiala, A Schäfer, S Wrenn, MN Pham… - Cell, 2020 - cell.com
… A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic…
that elicit potent and protective antibody responses against SARS-CoV-2 in mice. The …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

PJM Brouwer, TG Caniels, K van der Straten… - Science, 2020 - science.org
… mAb may explain its unusually strong neutralization potency. None of the epitopes of the
five RBD Fabs overlapped with that of CR3022, which is unable to neutralize SARS-CoV-2 (42), …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
… of a potent anti-spike neutralizing antibody, LY-CoV555, derived from a convalescent COVID-19
… displayed high affinity and potency due to its unique SARS-CoV-2 spike protein-binding …