[HTML][HTML] A comprehensive assessment of phytochemicals from Phyla nodiflora (L.) Greene as a potential enzyme inhibitor, and their biological potential: An in-silico, in …

A Alafnan, MF Nadeem, SF Ahmad, M Sarfraz… - Arabian Journal of …, 2023 - Elsevier
… /g extract) enzyme inhibition activity. … enzymes was highlighted by molecular docking
studies. In sum, this research showed that the studied extracts were effective as enzyme inhibitors

[图书][B] Evaluation of enzyme inhibitors in drug discovery: a guide for medicinal chemists and pharmacologists

RA Copeland - 2013 - books.google.com
… of interest in the quantitative evaluation of enzyme inhibitors for the applied sciences of drug
… If the resulting potential well of the enzymeinhibitor complex microstate(s) is deep enough, …

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics

R Tyagi, MA Elfawal, SA Wildman, J Helander… - Scientific reports, 2019 - nature.com
… CPT inhibitors repurposed for their anthelmintic potential 11 . … metabolic potential of nematodes,
requiring us to develop a … of inhibitors of key chokepoint enzymes that shared potentially

Phytochemical analysis and versatile in vitro evaluation of antimicrobial, cytotoxic and enzyme inhibition potential of different extracts of traditionally used Aquilegia …

H Jan, H Usman, M Shah, G Zaman, S Mushtaq… - … Medicine and Therapies, 2021 - Springer
evaluation of hyphae formation inhibition in Streptomyces 85E. The isolated compounds in
this reported study had showen impressive zone of inhibitioninhibit cancer proliferation [70]. …

One-pot multicomponent synthesis and bioevaluation of tetrahydroquinoline derivatives as potential antioxidants, α-amylase enzyme inhibitors, anti-cancerous and …

S Farooq, A Mazhar, A Ghouri, N Ullah - Molecules, 2020 - mdpi.com
… , the inhibition of the α-amylase enzyme was assessed in … , SF5 showed the maximum %
enzyme inhibition of 97.37%, … has the potential to inhibit COX-1 and COX-2 enzymes involved in …

Identification of potential inhibitor and enzyme-inhibitor complex on trypanothione reductase to control Chagas disease

MU Hossain, AR Oany, SAI Ahmad, MA Hasan… - … biology and chemistry, 2016 - Elsevier
… The efficacy of design inhibitor has been assessed with computational tools and compared
with available drugs using pharmacoinformatics analysis. These analyses indicate that …

Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability

S Žunec, D Vadlja, A Ramić, A Zandona… - International journal of …, 2023 - mdpi.com
… quinuclidines as inhibitors of human AChE … to assess their safety in the context of application
as potential therapeutics. Our results showed that all of the 14 tested quinuclidines inhibited

In silico and in vitro screening for carcinogenic potential of angiotensin-converting enzyme inhibitors and their degradation impurities

K Regulska, A Matera-Witkiewicz, A Mikołajczyk… - Toxicology and Applied …, 2023 - Elsevier
… the potential to genotoxic activity is a fundamental element of drug carcinogenic risk assessment
… Furthermore, the most recent ICH M7 (R1) “Assessment and control of DNA reactive (…

Cytochrome P450 enzymes: a review on drug metabolizing enzyme inhibition studies in drug discovery and development

SN Rao Gajula, MS Pillai, G Samanthula, R Sonti - Bioanalysis, 2021 - Taylor & Francis
Assessment of drug candidate's potential to inhibit cytochrome P450 (CYP) enzymes … Both
direct and time-dependent inhibition of drug metabolizing CYP enzymes by the concomitant …

An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies

J Strandell, A Neil, G Carlin - Phytomedicine, 2004 - Elsevier
inhibition of human cytochrome P-450 (CYP) enzymes. We … a critical potential for CYP enzyme
inhibition by commercial … human CYP enzyme 3A4, 2D6 and 2C19 inhibition assays. We …