SARS-COV-2 variants: differences and potential of immune evasion

SM Hirabara, TDA Serdan, R Gorjao… - Frontiers in cellular …, 2022 - frontiersin.org
… Omicron variant accumulates numerous mutations, including Q498R and S477N, which
have been previously associated with elevated binding to ACE2 receptor, potentially enhancing …

… SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 …

E Avolio, M Carrabba, R Milligan… - Clinical …, 2021 - portlandpress.com
… The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range
… of SARS-CoV-2 to infect vascular cells is still debated. Additionally, the SARS-CoV-2 Spike (…

Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2

S Pokhrel, TA Bouback, A Samad, SM Nur… - International Journal of …, 2021 - Elsevier
… that aids drug discovery by assaying a large number of potential drug-like compounds, whereby
the … Therefore, this study aimed to screen potential natural anti-COVID-19 compounds by …

Neuropilin‑1 as a new potential SARSCoV2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID19

J Davies, HS Randeva, K Chatha… - Molecular …, 2020 - spandidos-publications.com
… symptoms, such as the receptor for advanced glycation … potential role of NRP1 as an
additional SARS-CoV-2 infection mediator implicated in the neurologic manifestations of COVID-19. …

Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An: in silico: approach

SK Behera, N Mahapatra, CS Tripathy… - Indian Journal of …, 2021 - journals.lww.com
… by SARS-CoV-2. The objective of the present investigation was to repurpose the drugs with
potential antiviral activity against receptor-binding domain (RBD) of SARS-CoV-2 spike (S) …

Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy

JM Brimson, MI Prasanth, DS Malar… - Expert Opinion on …, 2021 - Taylor & Francis
… sigma-1 receptor and autophagy in SARS-CoV-2 infections and … , and deaths resulting from
SARS-CoV-2 and offer insights on … Expert opinion: Drugs with sigma affinity potentially offer …

Identification of potential binding sites of sialic acids on the RBD domain of SARS-CoV-2 spike protein

B Li, L Wang, H Ge, X Zhang, P Ren, Y Guo… - Frontiers in …, 2021 - frontiersin.org
… Syndrome Coronavirus (MERS-CoV), which can … receptors of many types of viruses. Therefore,
it is very interesting to determine whether sialic acid is a potential receptor of SARS-CoV-2

Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor

AA Al-Karmalawy, MA Dahab, AM Metwaly… - Frontiers in …, 2021 - frontiersin.org
… to repurpose them effectively for the potential treatment of COVID-19 infection. However, we
receptor and so prevent the entrance of SARS-CoV-2 through its spike protein (Figure 2). …

Current advancements and potential strategies in the development of MERS-CoV vaccines

N Zhang, S Jiang, L Du - Expert review of vaccines, 2014 - Taylor & Francis
… It was recently reported that mice transduced with adenoviral vectors expressing MERS-CoV’s
receptor DPP4 were susceptible to MERS-CoV infection, with the infected mice …

An overview of recent insights into the response of TLR to SARS-CoV-2 infection and the potential of TLR agonists as SARS-CoV-2 vaccine adjuvants

MEH Kayesh, M Kohara, K Tsukiyama-Kohara - Viruses, 2021 - mdpi.com
… In an in vitro study, it was shown that there was no inhibitory effect of famotidine, a histamine-2
receptor antagonist, on SARS-CoV-2 proteases [77]; however, although famotidine has …