Aging of the immune system. Mechanisms and therapeutic targets

CM Weyand, JJ Goronzy - Annals of the American Thoracic Society, 2016 - atsjournals.org
… shift the cell’s survival potential and differentiation pattern. Immune aging in RA T cells is also
… Altered metabolic patterns provide opportunities to therapeutically target the immune aging

[HTML][HTML] Targeting immune dysfunction in aging

S Borgoni, KS Kudryashova, K Burka… - Ageing research …, 2021 - Elsevier
… and new anti-aging therapeutic approaches targeting the immune system are being … the
potential to improve the health of multiple organ systems. Therefore, anti-aging immune targeting

The ageing immune system as a potential target of senolytics

PY Du, A Gandhi, M Bawa… - Oxford Open Immunology, 2023 - academic.oup.com
… increasing the efficacy of drugs whilst reducing potential side effects, as seen in … ageing
immune system is its diminished immune response, which in part is driven by senescent immune

Ageing and the immune system

RB Effros - Ageing Vulnerability: Causes and Interventions …, 2001 - Wiley Online Library
… stimulatedinvitro, it is possible that the aged environment is in some way favouring the more
… The key in that case may be the local immunity that has been induced in the target tissues (…

Opportunities and challenges of targeting an aging immune system

MJ Roesel, T Matsunaga, SG Tullius - Transplantation, 2021 - journals.lww.com
Targeting key players of the aging immune system may therefore … The transfer of these cells
has the potential to accelerate aging in … Thus, interfering with aging does appear possible. …

Immune system modulation in aging: Molecular mechanisms and therapeutic targets

B Cisneros, I García-Aguirre, J Unzueta… - Frontiers in …, 2022 - frontiersin.org
target to modulate immune responses during aging. … immunosenescence have therapeutic
potential. Owing to the … in macrophage-mediated inflammation, targeting of AP-1 has been …

Impact of aging immune system on neurodegeneration and potential immunotherapies

Z Liang, Y Zhao, L Ruan, L Zhu, K Jin, Q Zhuge… - Progress in …, 2017 - Elsevier
… In this review, we summarize recent discoveries linking the aging immune system with the …
potential rejuvenation strategies, focusing aimed at targeting the aging immune system in an …

The ageing immune system and its clinical implications

D Wordsworth, DK Dunn-Walters - Reviews in Clinical Gerontology, 2011 - cambridge.org
… cytotoxic T lymphocytes (CTL) induce apoptosis in target cells. The chief function of B cells is
… A large contributor to immunosenescence, and potentially to many age-related pathologies, …

Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy

J Conway, M Certo, JM Lord, C Mauro… - British journal of …, 2022 - Wiley Online Library
potential use of metabolic immunotherapeutic strategies targeting these processes in
counteracting immune … The ageing immune system and inflammageing. Many biological …

Aging of the immune system: focus on natural killer cells phenotype and functions

A Brauning, M Rae, G Zhu, E Fulton, TD Admasu… - Cells, 2022 - mdpi.com
targeting primary aging processes, but drivers of secondary … A potential approach to
reducing secondary aging of the immune system (including possibly NK function) in aging is …