Potential therapeutic strategies for skeletal muscle atrophy

L Huang, M Li, C Deng, J Qiu, K Wang, M Chang… - Antioxidants, 2022 - mdpi.com
… activation and denervation-induced skeletal muscle atrophy in the mouse model [55]. These
results indicate that ALKBH5 is a potential therapeutic target for neurogenic muscle atrophy. …

Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action

V Dutt, S Gupta, R Dabur, E Injeti, A Mittal - Pharmacological Research, 2015 - Elsevier
… In spite of many promising therapeutic targets for treating muscle wasting, not even a …
potential drugs (that are in use at laboratory/preclinical level of investigation using different atrophic

[HTML][HTML] Muscle atrophy in chronic obstructive pulmonary disease: molecular basis and potential therapeutic targets

E Barreiro, A Jaitovich - Journal of thoracic disease, 2018 - ncbi.nlm.nih.gov
… biological mechanisms that underlie muscle dysfunction and wasting in patients with COPD.
… of specific therapeutic targets that may alleviate muscle dysfunction and loss in patients with …

Strategies and potential therapeutic agents to counter skeletal muscle atrophy

Z Huang, J Zhu, W Ma, H Sun - Biotarget, 2018 - biotarget.amegroups.org
… on potential therapeutic strategies and mechanisms involved in muscle atrophy. … The
glucocorticoid-KLF15-BCAA pathway as a novel therapeutic target for muscular atrophy show us …

Metabolic remodeling in skeletal muscle atrophy as a therapeutic target

A Renzini, CS Riera, I Minic, C D'Ercole… - Metabolites, 2021 - mdpi.com
… of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a
therapeutic target … exercise as tools for counteracting muscle wasting in atrophic conditions. …

GEMINs: potential therapeutic targets for spinal muscular atrophy?

R Borg, RJ Cauchi - Frontiers in neuroscience, 2014 - frontiersin.org
The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the
most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor …

Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia

T Yoshida, AM Tabony, S Galvez, WE Mitch… - The international journal …, 2013 - Elsevier
loss and improves muscle strength. Thus the RAS is a promising target for the treatment of
muscle atrophy … article is part of a Directed Issue entitled: Molecular basis of muscle wasting. …

Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting

D Nury, C Doucet, O Coux - BMC biochemistry, 2007 - Springer
muscle wasting and figure 1, there are several levels of possible therapeutic intervention to
limit muscle wasting… either promote muscle hypertrophy (such as insulin or IGF-1) [79], inhibit …

[HTML][HTML] Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Q Xiao, CC Sun, CF Tang - Experimental Gerontology, 2023 - Elsevier
… maintaining skeletal muscle homeostasis, making it a potential therapeutic target for
improving skeletal muscle atrophy. Here, we review the pathogenesis of skeletal muscle atrophy, …

MicroRNAs as potential therapeutic targets for muscle wasting during cancer cachexia

AJ Sannicandro, B McDonagh… - Current Opinion in …, 2020 - journals.lww.com
… key genes involved in muscle wasting in cachexia are associated … the potential role of miR-181
in regulating muscle wasting [13] . … dynamics and muscle wasting during ageing [19,20] . …