The Immunomodulatory Role of Cell-Free Approaches in SARS-CoV-2-Induced Cytokine Storm—A Powerful Therapeutic Tool for COVID-19 Patients

M Csobonyeiova, V Smolinska, S Harsanyi… - Biomedicines, 2023 - mdpi.com
… so-called cytokine storm (CS), which activates various inflammatory cytokines that damage
… have been intensively trying to investigate the best treatment options; however, only limited …

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
cytokine release in response to viral infection, a condition known as cytokine release
syndrome (CRS) or cytokine storm… timed anti-inflammatory therapeutic strategies could improve …

[HTML][HTML] Nanomedicine therapies modulating macrophage dysfunction: a potential strategy to attenuate cytokine storms in severe infections

J Liu, M Wan, CJ Lyon, TY Hu - Theranostics, 2020 - ncbi.nlm.nih.gov
… These studies suggest the potential utility of macrophage depletion by liposomes, or other …
potential to induce a cytokine storm and its associated pathological effects. To the best of our …

Cytokine storm induced by SARS-CoV-2

P Song, W Li, J Xie, Y Hou, C You - Clinica chimica acta, 2020 - Elsevier
… an antiviral role, but a strong cytokine storm due to an unbalanced … to effectively suppress
cytokine storm is essential for … of IL-6 and has a therapeutic effect on cytokine storm caused

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
… In other words, the massive and continuous release of proinflammatory cytokines and …
damage induced by the cytokine storm triggered by SARS-CoV-2, as well as on potential therapies

Cytokine storm syndrome: looking toward the precision medicine era

EM Behrens, GA Koretzky - Arthritis & rheumatology, 2017 - Wiley Online Library
… Given the strong evidence of a central role of IFNg in FHLH, … immune system and the “sharper
tools” of rationally selected … for each therapy for use in specific subsets of cytokine storm (…

Can natural polyphenols help in reducing cytokine storm in COVID-19 patients?

G Giovinazzo, C Gerardi, C Uberti-Foppa, L Lopalco - Molecules, 2020 - mdpi.com
… Alterations in the inflammatory cytokines pathway represent a strong signature during
SARS-… supporting their role as therapeutic tools in different acute and chronic disorders [35,41,42]. …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
… The development and optimization of therapeutic strategies aimed at targeting chemokines
and/or their receptors could add relevant tools for the clinical management of patients with …

[HTML][HTML] Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage

N Pillalamarri, G Ren, L Khan, A Ullah, S Jonnakuti… - Translational …, 2021 - Elsevier
… A-NP) could induce cytotoxic T cell response potent enough to kill … induced activation of
EVs then calm down cytokine and stimulate the tissue repair process [123]. The therapeutic utility

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
… Likewise, the utility of a broad term such as “cytokine storm” … are already on therapies that
block IL-1 or IL-6. Despite its … mediators such as cytokines, which if strong enough will promote …