… Fixed dosing of oral targeted therapies is inadequate in the era of precision medicine. …
studies are needed to confirm the clinical value of precision dosing in oncology. PK-based …

… of precision dosing in oncology. For alectinib, a randomized study on TDM-guided dosing
is … that pharmacokinetically guided dose optimization of oral targeted therapies is feasible in …

… characteristics, most novel oral targeted anticancer agents are still … dosing approach. In this
review, we discuss the scientific evidence for dose individualization of oral targeted therapies …

… of targeted therapies. Based on these examples and the associated principles for the
implementation of precision dosing, … , real-world approach to the best use of precision medicines. …

… multiple different precision dosing strategies … precision dosing of targeted cancer medicines
and is followed by a comprehensive comparison of the nuances between precision dosing …

… precision dosing targets correct and the best for all patients? In this review, the types of precision
dosing targets … with the translatability of these targets to individual patients are identified…

… cascade of target-based agents and the difficult challenge of bringing individualized precision
… (PD) factors, and drug selection and dosing should take this into consideration to optimize …

… is the case for targeted therapies is debatable [3], creating opportunities for dose optimization
in … Table 1 Key characteristics and precision dosing strategies for the drug-based treatment …

… dosing, even within the controlled environment of a clinical trial. Although targeted therapies
… calculate initial safe doses, either within a clinical trial or in practice, for combinations of two …

… drugs should be prioritized for precision dosing, nor which drug and disease criteria should
be considered. Therefore, we propose that the need for precision dosing can be informed by …