Precision oncology by point-of-care therapeutic drug monitoring and dosage adjustment of conventional cytotoxic chemotherapies: a perspective

M Briki, P André, Y Thoma, N Widmer, AD Wagner… - Pharmaceutics, 2023 - mdpi.com
… In order to provide oncologists with assistance in dosage adjustment without relying on
the presence of a pharmacologist or pharmacist, model-informed precision dosing platforms …

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine

SL Groenland, RHJ Mathijssen, JH Beijnen… - European Journal of …, 2019 - Springer
… Imaging is usually performed every 8 to 12 weeks, while ideally dose adjustments should …
of tumor cells have already emerged and dose adjustments will probably be too late at this …

On precision dosing of oral small molecule drugs in oncology

AK Lyashchenko, S Cremers - British journal of clinical …, 2021 - Wiley Online Library
Precision oncology approaches have enabled matching of the best available anticancer …
of TDM-guided precision dosing, ie adjusting an individual's drug dose based on measured …

Reinforcement learning for precision oncology

JN Eckardt, K Wendt, M Bornhaeuser, JM Middeke - Cancers, 2021 - mdpi.com
… For every iteration, the agent then selects an action, for example, a dose adjustment on a
linear scale from 0 to 100%, given the state of the environment. This action will result in an …

[HTML][HTML] At the right dose: personalised (N-of-1) dosing for precision oncology

M Nikanjam, S Kato, JK Sicklick, R Kurzrock - European Journal of Cancer, 2023 - Elsevier
… cancer drugs is based on giving each patient the same dose (a flat dose) or a dose based
… drug dosing determined by starting at reduced doses and using intrapatient dose escalation …

Precision dosing of targeted therapies is ready for prime time

SL Groenland, RB Verheijen, M Joerger… - Clinical Cancer …, 2021 - AACR
… The purpose of this perspective is to discuss whether randomized studies are needed to
confirm the clinical value of precision dosing in oncology. PK-based dose adjustments are …

Molecular-guided off-label targeted therapy in a large-scale precision oncology program

V Vashistha, E Katsoulakis, A Guo, M Price… - … Precision Oncology, 2023 - ascopubs.org
… Time to first dose adjustment refers to reduction in dose, treatment break, or treatment …
Although the classification schema varies across the available precision oncology information …

Precision dosing of targeted anticancer drugs—challenges in the real world

HY Kim, JH Martin, AJ Mclachlan… - Translational Cancer …, 2017 - tcr.amegroups.org
Dose calculation based on body size (weight or surface area) could be described as
implementing a dose adjustment… examples in cancer treatment of dose adjustment based on a …

Nuances to precision dosing strategies of targeted cancer medicines

AM Hopkins, BD Menz, MD Wiese… - Pharmacology …, 2020 - Wiley Online Library
dose reduction guidelines for severe toxicity and adjustment of monoclonal antibody dose
according to body size, 1 precision dosing … the potential for precision dosing of targeted cancer …

Precision oncology: origins, optimism, and potential

V Prasad, T Fojo, M Brada - The Lancet Oncology, 2016 - thelancet.com
… of precision oncology alongside those of precision diagnostics … , will have to undergo
substantive adjustments before it can be … Treatment interruptions or dose delays—a marker of …