Potential antiviral drugs for SARS-Cov-2 treatment: preclinical findings and ongoing clinical research

S Bimonte, A Crispo, A Amore, E Celentano, A Cuomo… - in vivo, 2020 - iv.iiarjournals.org
… the SARS-Cov-2 outbreak (4). Different preclinical in vitro and in vivo studies on other
CoV-induced diseases suggested that promising clinical outcomes for SARS-Cov-2 patients …

Revisiting potential druggable targets against SARSCoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review

AAM Sohag, MA Hannan, S Rahman… - Drug development …, 2020 - Wiley Online Library
… , previous use of the drugs, and early findings of possible drug mechanisms. Moreover, our
review would provide insightful evidence for future SARS-CoV-2 research and might support …

The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)

P Pagliano, C Sellitto, T Ascione… - Expert Opinion on …, 2022 - Taylor & Francis
… results of preclinical investigations on MOV for SARS-CoV-2 … These findings
suggested that MOV concentration within … of SARS-CoV-2 transmission in some settings [Citation68]. …

[HTML][HTML] Viral kinetics of SARS-CoV-2 over the preclinical, clinical, and postclinical period

S Jang, JY Rhee, YM Wi, BK Jung - International Journal of Infectious …, 2021 - Elsevier
… been published on viral kinetics during the preclinical and clinical periods of SARS-CoV-2. …
In our finding, the Ct value is as low as 30 or less from 5 days before symptom onset to 10 …

Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine: preclinical studies

A Kandeil, A Mostafa, RR Hegazy, R El-Shesheny… - Vaccines, 2021 - mdpi.com
… Here, we describe the preclinical studies of the first Egyptian inactivated SARS-CoV-2 …
our findings, previous recent studies of Syrian hamsters challenged intranasally with SARS-CoV-2 …

Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates

G Sir Karakus, C Tastan, D Dilek Kancagi… - Scientific reports, 2021 - nature.com
… Hence, the findings of this study prompted us to plan a new in vivo experiment with the
second version of SK-01 and OZG-3861 (1 × 10 13 or 1 × 10 14 viral copies per dose) in …

Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant

W Phoolcharoen, B Shanmugaraj, N Khorattanakulchai… - Vaccine, 2023 - Elsevier
… Overall, these preclinical findings support further clinical development of Baiya SARS-CoV-…
In the present study, we describe the preclinical evaluation of our second-generation vaccine …

Preclinical assessment of IgY antibodies against recombinant SARS-CoV-2 RBD protein for prophylaxis and post-infection treatment of COVID-19

A Agurto-Arteaga, A Poma-Acevedo… - Frontiers in …, 2022 - frontiersin.org
… Figure 6 Histopathological findings in the lungs of hamsters challenged with SARS-CoV-2.
(A) Areas of necrosis with hemorrhage, thickened alveolar wall, and infiltration …

An overview of preclinical animal models for SARS-CoV-2 pathogenicity

I Munshi, A Khandvilkar, SM Chavan… - Indian Journal of …, 2021 - journals.lww.com
SARS-CoV-2 shares 79 and 50 per cent genome similarity with SARS-CoV and MERS-CoV,
respectively 1 . Further, SARS-CoV-2 genome shares 96.2 and 87 per cent similarity with …

Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

B Shanmugaraj, N Khorattanakulchai, C Panapitakkul… - Vaccine, 2022 - Elsevier
… , preclinical safety and toxicity of this plant-produced subunit vaccine candidate, Baiya
SARS-CoV… This finding indicates that the Baiya SARS-CoV-2 Vax 1 vaccine adjuvanted with alum-…