… and are expected to provide quantitative predictions. The aim of this paper is to … predict
clinical pharmacokinetics and DDIs of drugs or NMEs that are substrates of hepatic transporters…

… on the clinical pharmacokinetics of new drug candidates in the early … prediction of clinically
relevant transporter-mediated DDIs (TP-DDIs) and pharmacogenetics of drug transporters, …

… with systemic disposition determined by both transporters and metabolic enzymes. However…
based pharmacokinetic modeling strategies. Emerging data on the expression of transporter …

… proteomics method may provide a fast and cost-effective approach to provide reasonable
estimates of protein concentrations for hepatic transporters and drug metabolizing enzymes. …

… Recent years have seen great advances in our ability to predict transporter-mediated
pharmacokinetics and drug interactions. Decision trees for determining when clinical drug …

… of hepatic transporters in pharmacokinetics and drug-drug interactions (DDIs). Special
emphasis is placed on transporters with … Hepatic and intestinal drug transporters: prediction of …

… transporter activities on the systemic and liver exposure of pravastatin using a physiologically
based pharmacokinetic … of pravastatin in rats for the hepatic uptake and canalicular efflux, …

… role in intersubject pharmacokinetics (PK) variability,[Citation6] transporter genetics may …
Prediction of hepatic uptake transporter-mediated DDIs can be achieved with a simplified static …

… This report summarizes the use of PBPK to evaluate the contribution of major transporters
in the intestine (P-gp), liver (organic anion transporting peptide OATP), and kidneys (organic …

… to predict hepatic clearance of … hepatic transporters play a pivotal role in hepatic drug
clearance, efforts have been made to incorporate the action of transporters into pharmacokinetic …