… in the liver, blood-brain barrier), predicting TC is important to … IVIVE scaling approaches
to predict transporter-based CL, … approaches can be used to predict transporter-based DDI. …

… and show regional differences in enzymatic and transporter activities. This limits the … sound
rationale, enables more accurate and precise predictions of hepatic CL (CLH) and VD to be …

… protein 2 (MRP2), an efflux transporter at the apical membranes of liver, kidney, gastrointestinal
tract and placenta similar to BCRP. The model could be extended to include these …

… , SCHHs maintain hepatic transporter expression and functional activity and appear to be a
well characterized an in vitro model for the prediction of in vivo human pharmacokinetics. Rif …

… transporters) determine the hepatic clearance of a drug … The ECM can help predict whether
transporters or metabolic … of DDIs and SNPs on these predictions (Table 1, Supplementary S4…

… of predicted hepatic clearance (CL H , predicted from … with no adjustment for being a transporter
substrate) and the fraction … Prediction of pharmacokinetic properties using experimental …

… predict human PK of OATP1B1 substrates for carriers of SLCO1B1 variants through
physiologically based pharmacokinetic (… the ability to predict the pharmacokinetics in the liver, …

… The transporter is assumed to be present in the gut wall, liver (on the apical canalicular
membrane), and kidney (on the apical membrane), resulting in drug secretion in the gut lumen, …

… with the liver levels could be quantitatively predicted by … hepatic uptake transporters may
lead to changes in V ss and species differences in the transporters may lead to poor predictions …

… In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for
the prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …