Aims In the Digitalis Investigation Group (DIG) trial, digoxin reduced mortality or hospitalization
due to heart failure (HF) in several pre‐specified high‐risk subgroups of HF patients, but …

… was collected by voluntary patient reporting, limiting the ability to investigate the impact of
apabetalone in patients with established heart failure in the current analysis. Finally, given that …

… LVEF, thus precluding the ability to perform pooled analyses with other outcome studies.
While this analysis was prespecified in the academic statistical analysis plan, it is one of many …

… The number of patients with chronic heart failure (HF) continues to increase worldwide, and
… for patients with mild-to-moderate heart failure reduces its progression and mortality risk [3]. …

Aims This prespecified analysis of the FIDELIO‐DKD trial compared the effects of finerenone,
a selective non‐steroidal mineralocorticoid receptor antagonist, on cardiorenal outcomes …

… In this prespecified analysis, we describe in detail the efficacy of dapagliflozin on total HF
events, ie, first and subsequent HF hospitalizations or urgent visits for HF and cardiovascular …

… to frailty status in patients with heart failure with mildly reduced or … of Patients With Preserved
Ejection Fraction Heart Failure). … In this prespecified analysis, we examined the efficacy and …

… In the pre-specified primary analysis, we pooled participants … The primary endpoint for this
analysis was the composite of … The secondary endpoint was the pre-specified renal composite …

… We prespecified … We prespecified a sensitivity analysis that was restricted to those studies
judged as low risk of bias on our validityassessment and we prespecified subgroup analyses …

… a prespecified analysis of the randomized, double-blind, placebo-controlled ADVOR trial that
enrolled 519 patients with acute heart failure (… The current work is a prespecified analysis of …