Circular RNA vaccine in disease prevention and treatment

D Niu, Y Wu, J Lian - Signal transduction and targeted therapy, 2023 - nature.com
… We also summarize and discuss the current methodological research for circRNA vaccine
… of circRNA vaccine and its potential applications in diseases treatment and prevention. …

New insights on circular RNAs and their potential applications as biomarkers, therapeutic agents, and preventive vaccines in viral infections: with a glance at SARS …

N Rahmani-Kukia, A Abbasi - Molecular Therapy-Nucleic Acids, 2022 - cell.com
RNA (ceRNA) network, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs),
and circular RNAs (… CircRNAs, as a group of non-encoded RNAs, make a loop-like structure …

Circular RNA: a promising new star of vaccine

J Xie, F Ye, X Deng, Y Tang, JY Liang… - Journal of translational …, 2023 - degruyter.com
… Third, circRNA-LNPs exhibited greater thermostability than linear mRNA-LNP vaccines. The
literature reported that circular RNA vaccines encapsulated in LNPs were conserved well for …

Research progress on circular RNA vaccines

Y Bai, D Liu, Q He, J Liu, Q Mao, Z Liang - Frontiers in immunology, 2023 - frontiersin.org
… ) vaccines, biopharmaceutical companies and research teams worldwide have attempted to
develop more stable circular RNA (circRNA) vaccines … process of circRNA vaccines. Further, …

Vaccines' new era-RNA vaccine

W Zhou, L Jiang, S Liao, F Wu, G Yang, L Hou, L Liu… - Viruses, 2023 - mdpi.com
… The self-adjuvant effect of mRNA-lipid nanoparticle (LNP) formulations or circular RNA
further enhances the potential of RNA vaccines. However, some challenges need to be …

Circular RNAs in cardiovascular diseases: regulation and therapeutic applications

L Wang, G Xu, M Spanos, G Li, Z Lei, JPG Sluijter… - Research, 2023 - spj.science.org
… coronavirus disease vaccine development and implementation, many mRNA vaccines
are … The advantage of circRNA over other RNA vaccine technologies is that it utilizes cap-…

Circular RNA vaccines with long-term lymph node-targeting delivery stability after lyophilization induce potent and persistent immune responses

J Wan, Z Wang, L Wang, L Wu, C Zhang, M Zhou… - Mbio, 2024 - Am Soc Microbiol
… We employed the group I intron autocatalysis strategy (7) to produce circular RNAs
encoding glycoproteins of the RABV vaccine strain SAD-L16, termed circRNA-G (Fig. 1A). By …

In vitro transcribed RNA-based platform vaccines: past, present, and future

AD Perenkov, AD Sergeeva, MV Vedunova, DV Krysko - Vaccines, 2023 - mdpi.com
… of mRNA technology is circular RNA vaccines, which were … Circular RNA has several
advantages over mRNA vaccines … -amplifying mRNA, and circular RNA platforms created on its …

Functions and potential applications of circular RNAs in cancer stem cells

Z Feng, S Meng, H Zhou, Z Xu, Y Tang, P Li… - Frontiers in …, 2019 - frontiersin.org
circular RNAs were introduced into HeLa cells. In addition, the results suggested that the
translation initiation on these circular RNAs is … to total RNA vaccines or cell-based vaccines, the …

Functions of circular RNA in human diseases and illnesses

A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs are found to interact with RNA, proteins, and … Circular RNAs interfere with
various signaling pathways and take … of mRNA vaccines because of circRNA’s circular structure. …