… dots in emerging mast cell research: do factors affecting mast cell activation provide a missing link between adverse COVID-19 outcomes and the social determinants …

R da Silveira Gorman, IU Syed - Medical Sciences, 2022 - mdpi.com
… associated with adverse social determinants of health is urgently … Primary care physicians,
specialists, and public health … treating COVID-19 cytokine storm including mast cell stabilizing …

Myeloid autophagy genes protect mice against fatal TNF-and LPS-induced cytokine storm syndromes

YT Wang, A Sansone, A Smirnov, CL Stallings… - Autophagy, 2023 - Taylor & Francis
… define the genetic determinants of the immunopathogenesis … CIMs have been shown
to recapitulate primary bone marrow-… underlie the pathogenesis of cytokine storm in vivo. …

Understanding COVID-19 in children: immune determinants and post-infection conditions

GA Rotulo, P Palma - Pediatric research, 2023 - nature.com
… regulatory cells in children helps to avoid the cytokine storm while the causes of the intense
… generally recovered from a mild or asymptomatic primary infection, suggests that MIS-C is …

COVID-19 biology: cytokine storms and their implications

N Atceken, G Kozalak - Stem Cells, 2024 - Elsevier
… IFN-I cytokine response is the primary step of the protective immune response and is vital
in viral infections. The IFN-I response is the first step of the protective response and has …

Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm

Y Zhang, Q Yang, Q Peng, Z Tian, F Lv, X Zeng… - Frontiers in …, 2024 - frontiersin.org
… leading to polyamine deficiency may be the primary cause of cytokine storm induced by
EV71 infection, which suggests that inhibiting cytokine storm caused by EV71 infection through …

Immunity, sex hormones, and environmental factors as determinants of COVID-19 disparity in women

S Rehman, V Ravinayagam, I Nahvi… - Frontiers in …, 2021 - frontiersin.org
Primary differentiated human nasal epithelial cell cultures … Nasal epithelial cells are the
primary cell type infected with IAV… COVID-19 exhibit cytokine storm syndrome due to neutrophils. …

Silibinin and SARS-CoV-2: dual targeting of host cytokine storm and virus replication machinery for clinical management of COVID-19 patients

J Bosch-Barrera, B Martin-Castillo, M Buxó… - Journal of clinical …, 2020 - mdpi.com
… The RdRp coronaviral replication/transcription machinery is considered a primary target for
… known to antagonize JAK signaling are crucial determinants of virulence, it could be argued …

Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms

AL Rothman - Nature Reviews Immunology, 2011 - nature.com
… virus infection than during primary infection. However, even during primary infection, dengue
… hospitalization during primary infection in the first year of life 11,12 , as discussed below. …

[HTML][HTML] Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection

JR Teijaro, KB Walsh, S Cahalan, DM Fremgen… - Cell, 2011 - cell.com
… endothelial signaling loop that is important for the initiation of cytokine storm. We reveal that
… direct result of diminished infiltration of NK cells, the primary source of IFN-γ at this time point…

Silent Hypoxemia” Leads to Vicious Cycle of Infection, Coagulopathy and Cytokine Storm in COVID-19: Can Prophylactic Oxygen Therapy Prevent It?

A Chauhan, R Kaur, P Chakrbarti, A Pal - Indian Journal of Clinical …, 2021 - Springer
… During the initial stage of the pandemic, the primary symptom of COVID-19 was reported
to … -1β secretion, which are the key determinants of acute thrombotic events during hypoxic …