Murine models of secondary cytokine storm syndromes

E Brisse, CH Wouters, P Matthys - Cytokine Storm Syndrome, 2019 - Springer
… Hemophagocytic lymphohistiocytosis (HLH) comprises a broad spectrum of life-threatening
cytokine storm syndromes, classified into primary (genetic) or secondary (acquired) HLH. …

[HTML][HTML] An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

L Sanchez-Burgos, G Gómez-López, F Al-Shahrour… - Scientific Reports, 2022 - nature.com
… development of an inflammatory “cytokine storm” (CS) plays a determinant role. Here, we …
, which validates our approach as this is the primary treatment for this pathology. Interestingly, …

Comparison of the characteristics of cytokine storm and immune response induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 infections

T Liu, M Feng, Z Wen, Y He, W Lin… - Journal of inflammation …, 2021 - Taylor & Francis
Cytokine storm (CS) is a … cytokines and chemokines lead to acute lung injury and acute
respiratory distress syndrome (ARDS). This review compares the characters of cytokine storms

[HTML][HTML] The critical impacts of cytokine storms in respiratory disorders

SR Tramboo, AME Elkhalifa, S Quibtiya, SI Ali… - Heliyon, 2024 - cell.com
Cytokine storm refers to a dysregulated and excessive immune response characterized
by the release of a large number of pro-inflammatory cytokines into the bloodstream. This …

[HTML][HTML] Elevated expression of AhR and NLRP3 link polycyclic aromatic hydrocarbon exposure to cytokine storm in preschool children

Z Cheng, X Huo, Y Dai, X Lu, MN Hylkema… - Environment international, 2020 - Elsevier
… However, the potential of PAHs to lead to a cytokine storm associated with AhR (aryl …
Our findings suggest that the association between PAH exposure and a cytokine storm may …

[HTML][HTML] Pyruvate kinase M2 nuclear translocation regulate ferroptosis-associated acute lung injury in cytokine storm

H Wang, C Fan, X Chen, W Zhou, L Guo, F Zhao, S Ye… - Inflammation, 2024 - Springer
Cytokine storm (CS) is linked with macrophage dysfunction and acute lung injury (ALI), which
… hyper-inflammatory state or cytokines storm syndrome with aberrant ferroptotic cell death. …

[HTML][HTML] Understanding the genetic determinant of severity in viral diseases: a case of SARS-Cov-2 infection

BO Oladejo, CF Adeboboye, TT Adebolu - Egyptian Journal of Medical …, 2020 - Springer
… for development of ARDS is cytokine storm [26, 27]. Cytokine storm arises from the release
… to clear hepatitis C virus spontaneously during primary infection. In some cases of human …

Targeting cytokine storm in COVID-19: what have we learned?

PM Ridker - European Heart Journal Open, 2021 - academic.oup.com
… form of cytokine release syndrome is a major determinant of … As reported, there was no
difference in the trial primary … show no significant benefit for the primary trial endpoint of death or …

Cytokine production by primary human macrophages infected with highly pathogenic H5N1 or pandemic H1N1 2009 influenza viruses

S Sakabe, K Iwatsuki-Horimoto, R Takano, CA Nidom… - 2011 - microbiologyresearch.org
… the cytokine-mediated pathogenesis of this infection in humans, we measured various cytokines
produced by primary … We found that many cytokines were produced at higher levels on …

Failure of treatments based on the cytokine storm theory of sepsis: time for a novel approach

EJ Giamarellos-Bourboulis - Immunotherapy, 2013 - Taylor & Francis
… from agents that inhibit the cytokine storm. Most of these trials … that inhibit the proinflammatory
cytokine storm useless and if … infections (IAIs) and primary bacteremia where start of the …