Vandetanib blocks the cytokine storm in SARS-CoV-2-infected mice

AC Puhl, GF Gomes, S Damasceno, EJ Fritch… - ACS …, 2022 - ACS Publications
… Studies have revealed higher levels of cytokine storm associated with more severe COVID-19
development. (12) In these patients, the inflammatory substances from the cytokine storm

Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signaling

BK Gajjela, MM Zhou - Drug discovery today, 2022 - Elsevier
… a crucial determinant of virulence, acting to promote the overexpression of proinflammatory
… and reduces viral infectivity in human primary liver spheroids. Furthermore, Baricitinib also …

The preventive effect of Xuebijing injection against cytokine storm for severe patients with COVID-19: a prospective randomized controlled trial

Z Luo, W Chen, M Xiang, H Wang, W Xiao, C Xu… - European journal of …, 2021 - Elsevier
… The primary outcome was the level of peripheral blood lymphocyte and … cytokine release
is considered to be the determinant of ARDS [9,27]. Prevention and mitigation of cytokine storm

[HTML][HTML] Red blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery

E Viikinkoski, J Jalkanen, J Gunn, T Vasankari… - Scientific reports, 2021 - nature.com
… The primary outcome of this study was the evaluation of cytokine IL-6 and HIF-1α levels in
respect with RBC transfusion during surgery and/or within 12 h from surgery. The secondary …

[HTML][HTML] A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome …

A Bektas, SH Schurman, C Franceschi, L Ferrucci - Immunity & Ageing, 2020 - Springer
… For instance, vesicular stomatitis virus replication is markedly impaired in both primary and
… The unopposed viral load may be a major determinant of the cytokine storm, although with a …

Potential pathophysiological mechanisms underlying multiple organ dysfunction in cytokine release syndrome

P Chen, Y Tang, W He, R Yang, Z Lan… - Mediators of …, 2022 - Wiley Online Library
… different diseases trigger cytokine storms by different initiation … This drug blocks cytokine
storms in primary hemophagocytic … occur in many diseases and are a key determinant of poor …

[HTML][HTML] Primary dengue virus infections induce differential cytokine production in Mexican patients

SI de la Cruz Hernández, HN Puerta-Guardo… - Memorias do Instituto …, 2016 - SciELO Brasil
… Recent advances in deciphering viral and host determinants of dengue virus replication and
… Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat …

[HTML][HTML] From Cytokine Storm to Cytokine Breeze: Did Lessons Learned from Immunopathogenesis Improve Immunomodulatory Treatment of Moderate-to-Severe …

G Rondovic, D Djordjevic, I Udovicic, I Stanojevic… - Biomedicines, 2022 - mdpi.com
… Bearing in mind that a “cytokine storm” is not present in the majority of COVID-19 patients,
it is to be expected that the path to the adequate choice of a second immunomodulatory drug …

Altered T-bet Dominance in IFN-γ–Decoupled CD4+ T Cells with Attenuated Cytokine Storm and Preserved Memory in Influenza

A Dutta, SC Miaw, JS Yu, TC Chen, CY Lin… - The Journal of …, 2013 - journals.aai.org
primary infection, instead of the decoupled clonotypic CD4 + T cells themselves. Additional
control experiments were performed with heterologous influenza virus strains for the primary

Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

A Mahmud-Al-Rafat, A Majumder, KMT Rahman… - Cytokine, 2019 - Elsevier
cytokines that are caught up in a cytokine storm, IL-6 is of primary interest because of its role
as transition cytokine… during cytokine storm-mediated immunopathogenesis, IL-6 provides a …