Altered T-bet Dominance in IFN-γ–Decoupled CD4+ T Cells with Attenuated Cytokine Storm and Preserved Memory in Influenza

A Dutta, SC Miaw, JS Yu, TC Chen, CY Lin… - The Journal of …, 2013 - journals.aai.org
primary infection, instead of the decoupled clonotypic CD4 + T cells themselves. Additional
control experiments were performed with heterologous influenza virus strains for the primary

Hyperinflammatory response in COVID-19: a systematic review

MJA Silva, LR Ribeiro, MIM Gouveia, BR Marcelino… - Viruses, 2023 - mdpi.com
… The “cytokine storm” itself brings several complications to the host through … after
inflammatory reactions in which inflammation itself is the primary response to tissue damage [30]. …

The most important biomarker associated with coagulation and inflammation among COVID-19 patients

LZ Hong, ZX Shou, DM Zheng, X Jin - Molecular and Cellular Biochemistry, 2021 - Springer
… The primary coagulopathy of COVID-19 is marked by a … Inflammatory biomarkers
including CRP, LDH, and IL-6 are … Infection followed by cytokine storm leads to more severe …

[HTML][HTML] Targeted counteracting of overactive macrophages by melittin stable-loaded solid lipid nanoparticles alleviates cytokine storm and acute inflammatory injury

Y Zheng, N Ye, Y Yang, M He, S Shi, Y Zhang… - Biomedicine & …, 2024 - Elsevier
… recruit adapter molecules, such as myeloid differentiation primary response 88, to activate the
… This phenomenon coupled with the key pathogenic determinant of activated macrophages …

Long peptide vaccination can lead to lethality through CD4+ T cell-mediated cytokine storm

H Kitamura, C Sedlik, A Jacquet… - The Journal of …, 2010 - journals.aai.org
… Massive cytokine storm and multiorgan failure were observed in six healthy volunteers who
… TNF-α was identified as the key effector of a cytokine storm that induced death and was …

Myeloid autophagy genes protect mice against fatal TNF-and LPS-induced cytokine storm syndromes

YT Wang, A Sansone, A Smirnov, CL Stallings… - Autophagy, 2023 - Taylor & Francis
… define the genetic determinants of the immunopathogenesis … CIMs have been shown
to recapitulate primary bone marrow-… underlie the pathogenesis of cytokine storm in vivo. …

Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectives

CM Batista, L Foti - International Immunopharmacology, 2021 - Elsevier
cytokine storm has been observed in patients with severe disease characterized by a
proinflammatory cytokine … Thus, some treatment strategies focus on anti-cytokine storm nAbs. This …

Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients

A Daneshkhah, V Agrawal, A Eshein… - Aging clinical and …, 2020 - Springer
… in reducing cytokine storm and … of cytokine production [9]. Clinical data obtained from
COVID-19 patients in China showed high concentrations of cytokines and possible cytokine storm

Genetic polymorphisms complicate COVID-19 therapy: pivotal role of HO-1 in cytokine storm

EW Fakhouri, SJ Peterson, J Kothari, R Alex, JI Shapiro… - Antioxidants, 2020 - mdpi.com
… The inflammatory response manifested by increased cytokine … disease with a baseline excess
of cytokines. The majority of the … to treat/prevent cytokine storm. Current therapy must focus …

Immune system changes in those with hypertension when infected with SARS-CoV-2

S Su, R Chen, S Zhang, H Shu, J Luo - Cellular Immunology, 2022 - Elsevier
… in primary hypertension with … a cytokine storm. Hypertensive patients are in a special immune
state, which hints the inflammatory response is more serious and the risk of cytokine storm