Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

CM Su, L Wang, D Yoo - Scientific reports, 2021 - nature.com
… of proinflammatory cytokines has been observed in COVID-19proinflammatory cytokine
expressions, and thus, we examined NF-κB-mediated proinflammatory cytokine gene expression

Expression of elevated levels of proinflammatory cytokines in SARSCoV‐infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis …

L He, Y Ding, Q Zhang, X Che, Y He… - The Journal of …, 2006 - Wiley Online Library
… syndrome (SARS) and that the SARS coronavirus (SARS-CoV) … expression of
angiotensin-converting enzyme 2 (ACE2), SARS-CoV spike (S) protein, and some pro-inflammatory

SARS-CoV-2/ACE2 interaction suppresses IRAK-M expression and promotes pro-inflammatory cytokine production in macrophages

I Pantazi, AA Al-Qahtani, FS Alhamlan… - Frontiers in …, 2021 - frontiersin.org
… , our study demonstrated that SARS-CoV-2 promoted inflammatory cytokine expression and
… development of cytokine storm observed in COVID-19 patients. Thus, IRAK-M expression in …

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

CJ Neufeldt, B Cerikan, M Cortese, J Frankish… - Communications …, 2022 - nature.com
pro-inflammatory cytokines, specifically IL-6, and lacked type I/III IFNs. We also demonstrate
that SARS-CoV-2 … of TNF expression in A549-ACE2 cells results from virus infection and is …

Macrophages and dendritic cells are not the major source of pro-inflammatory cytokines upon SARS-CoV-2 infection

MA Niles, P Gogesch, S Kronhart… - Frontiers in …, 2021 - frontiersin.org
pro-inflammatory cytokines is still under discussion. Surprisingly, we could not observe
production of pro-inflammatory cytokines by SARS-CoV-2 … plot showing the IL-6 expression of M2 …

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

VJ Costela-Ruiz, R Illescas-Montes… - Cytokine & growth factor …, 2020 - Elsevier
COVID-19 disease, caused by infection with SARS-CoV-2, is … of mainly proinflammatory
cytokines, such as IL-1, IL-6, IL-12, … expression of different cytokines in patients with COVID-19

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
SARS-CoV-2 may escape these defense mechanisms either by the induction of T … exhaustion
of these cells due to the expression of pro-inflammatory cytokines [79]. Severe lymphopenia…

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

M Zheng, R Karki, EP Williams, D Yang… - Nature …, 2021 - nature.com
… of proinflammatory cytokines and chemokines during COVID… in SARS-CoV-2-induced
cytokine and chemokine expression… cells (PBMCs) with SARS-CoV-2 in the presence of a TLR2 …

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

S Jalloh, J Olejnik, J Berrigan, A Nisa, EL Suder… - PLoS …, 2022 - journals.plos.org
… In this study, we examined the role of CD169 in facilitating SARS-CoV-2 infection of ACE2-deficient
human macrophages and its effect on inducing pro-inflammatory cytokine expression

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

L Runfeng, H Yunlong, H Jicheng, P Weiqi… - Pharmacological …, 2020 - Elsevier
Pro-inflammatory cytokine expression levels upon SARS-CoV-2 infection in Huh-7 cells …
Vero E6 cells and markedly reduced pro-inflammatory cytokines (TNF-α, IL-6, CCL-2/MCP-1 and …